ORG 24598 LITHIUM SALT

Product Name
ORG 24598 LITHIUM SALT
CAS No.
722456-08-8
Chemical Name
ORG 24598 LITHIUM SALT
Synonyms
ORG 24598 LITHIUM SALT;KEGXIIFRCYASEJ-ZEECNFPPSA-N;R-(-)-N-METHYL-N-[3-[(4-TRIFLUOROMETHYL)PHENOXY]-3-PHENYL-PROPYL]GLYCINE LITHIUM SALT
CBNumber
CB9827439
Molecular Formula
C19H21F3LiNO3
Formula Weight
375.32
MOL File
Mol file
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ORG 24598 LITHIUM SALT Property

storage temp. 
2-8°C
solubility 
H2O: >2mg/mL
form 
solid
color 
white to off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
O674978
Product name
Org 24598 lithium salt
Packaging
5mg
Price
$80
Updated
2021/12/16
Usbiological
Product number
256118
Product name
Org 24598 lithium salt
Packaging
10mg
Price
$466
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
OGM0000748
Product name
ORG 24598 LITHIUM SALT
Purity
95.00%
Packaging
5MG
Price
$702.59
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
OGM0000748
Product name
ORG 24598 LITHIUM SALT
Purity
95.00%
Packaging
25MG
Price
$1015.08
Updated
2021/12/16
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ORG 24598 LITHIUM SALT Chemical Properties,Usage,Production

Uses

Org 24598 Lithium Salt is a selective glycine transporter-1 (GlyT-1) inhibitor.

Biochem/physiol Actions

Org 24598 is a selective, potent inhibitor of glial GlyT (GlyT1, glycine transporter type 1). In rats (P12-P16) and in the presence of kynurenic acid, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and bicuculline, ORG 24598 at a concentration of 10 μM induced a mean inward current of -10/-50 pA at -60 mV and increased significantly the decay time constants of miniature (mIPSCs), spontaneous (sIPSCs) and electrically evoked glycinergic (eIPSCs) inhibitory postsynaptic currents. Replacing extracellular sodium with N-methyl-d-glucamine or superfusing the slice with micromolar concentrations of glycine also increased the decay time constant of glycinergic IPSCs. Glycine (1-5 μM and d-serine (10 μM) increased the amplitude of eEPSCs whereas l-serine had no effect. Org 24598 increased significantly the amplitude of NMDA receptor-mediated eEPSCs without affecting the amplitude of non-NMDA receptor-mediated eEPSCs. This brings conclusion that blocking glial glycine transporter by Org 24598 increased the level of glycine in spinal cord slices, which in turn prolonged the duration of glycinergic synaptic current and potentiated the NMDA-mediated synaptic response.

ORG 24598 LITHIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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ORG 24598 LITHIUM SALT Suppliers

CHINA 6 Switzerland 1 United Kingdom 2 United States 4 Global 13
Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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China
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EMMX Biotechnology LLC
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888-539-0666
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info@emmx.com
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Career Henan Chemica Co
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+86-0371-86658258 +8613203830695
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0371-86658258
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laboratory@coreychem.com
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China
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CONIER CHEM AND PHARMA LIMITED
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+8618523575427
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sales@conier.com
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ApexBio Technology
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sales@apexbt.com
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United States
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722456-08-8, ORG 24598 LITHIUM SALTRelated Search:


  • ORG 24598 LITHIUM SALT
  • R-(-)-N-METHYL-N-[3-[(4-TRIFLUOROMETHYL)PHENOXY]-3-PHENYL-PROPYL]GLYCINE LITHIUM SALT
  • KEGXIIFRCYASEJ-ZEECNFPPSA-N
  • 722456-08-8
  • C19H19F3LiNO3