ChemicalBook > CAS DataBase List > JTE 907

JTE 907

Product Name: JTE 907
CAS No.: 282089-49-0
Chemical Name: JTE 907
Synonyms: JTE 907;JTE907 (JTE-907;JTE-907, 10 mM in DMSO;N-(benzo[d][1,3]dioxol-5-ylMethyl)-7-Methoxy-2-oxo-8-(pentyl;N-(Benzo[d][1,3]dioxol-5-ylmethyl)-2-hydroxy-7-methoxy-8-(pentyloxy)quinoline-3-carboxamide;N-(1,3-BENZODIOXOL-5-YLMETHYL)-1,2-DIHYDRO-7-METHOXY-2-OXO-8-(PENTYLOXY)-3-QUINOLINECARBOXAMIDE;3-QuinolinecarboxaMide,N-(1,3-benzodioxol-5-ylMethyl)-1,2-dihydro-7-Methoxy-2-oxo-8-(pentyloxy)-;N-(benzo[d][1,3]dioxol-5-ylmethyl)-7-methoxy-2-oxo-8-(pentyloxy)-1,2-dihydroquinoline-3-carboxamide;N-(Benzo[d][1,3]dioxol-5-ylMethyl)-7-Methoxy-2-oxo-8-(pentyloxy)-1,2-dihydro-quinolin-3-carboxaMide
CBNumber: CB9829695
Molecular Formula: C24H26N2O6
Formula Weight: 438.47
MOL File: 282089-49-0.mol

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JTE 907 Property

Boiling point:: 704.2±60.0 °C(Predicted)
Density: 1.267±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥10mg/mL
pka: 9.49±0.70(Predicted)
form: Powder
color: white to off-white

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
RTECS: VB1150900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: J4330
Product name: JTE-907
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $243
Updated: 2022/05/15

Cayman Chemical

Product number: 10009857
Product name: JTE-907
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 10009857
Product name: JTE-907
Purity: ≥98%
Packaging: 5mg
Price: $239
Updated: 2024/03/01

Tocris

Product number: 2479
Product name: JTE907
Purity: ≥99%(HPLC)
Packaging: 10
Price: $227
Updated: 2021/12/16

Tocris

Product number: 2479
Product name: JTE907
Purity: ≥99%(HPLC)
Packaging: 50
Price: $952
Updated: 2021/12/16

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JTE 907 Chemical Properties,Usage,Production

Description

JTE-907 is a selective peripheral cannabinoid (CB₂) receptor agonist with K_d values of 25 and 2,370, 1.55 and 1,060, and 0.38 and 1,050 nM for human, mouse, and rat CB₂ and CB₁ receptors, respectively. It increases forskolin-stimulated cAMP production in CHO cells expressing human and mouse CB₂ in a dose-dependent manner. In vivo, JTE-907 inhibits carrageenin-induced edema in mouse paws with an ED₅₀ value of 0.05 mg/kg. JTE-907 also inhibits spontaneous scratching in a mouse model of chronic dermatitis at doses of 1 and 10 mg/kg.

Uses

Potent and selective ligands for cannabinoid type 2 receptors (CB2Rs) may have therapeutic potential for treating CB2Rs related inflammatory diseases (1). JTE 907 is a selective cannabinoid CB2 receptor inverse agonist with anti-inflammatory properties (2,3). Synthetic cannabinoids

Definition

ChEBI: N-(1,3-benzodioxol-5-ylmethyl)-7-methoxy-2-oxo-8-pentoxy-1H-quinoline-3-carboxamide is a member of quinolines and an aromatic amide.

Biological Activity

Highly selective cannabinoid CB 2 receptor inverse agonist. Binds with high affinity to rat, mouse and human CB 2 receptors (K i values are 0.38, 1.55 and 35.9 nM respectively). Produces anti-inflammatory effects in vivo .

Biochem/physiol Actions

JTE-907 is a cannabinoid CB2 ligand (inverse agonist). CB2 cannabanoid receptors are expressed in periferal nerves and other non CNS tissues, but are not expressed in the brain. CB2 is believed to have a role in nociceptive pain, but additional functions pertaining to the immune system have yet to be determined. CB2 selective agonists and antagonists provide a necessary tool for functional analyses.

storage

Store at RT

References

[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] MARCO GENTILI . Selective CB2 inverse agonist JTE907 drives T cell differentiation towards a Treg cell phenotype and ameliorates inflammation in a mouse model of inflammatory bowel disease[J]. Pharmacological research, 2019, 141: Pages 21-31. DOI: 10.1016/j.phrs.2018.12.005
[3] TATSUYA MAEKAWA . The cannabinoid CB2 receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis[J]. European journal of pharmacology, 2006, 542 1: Pages 179-183. DOI: 10.1016/j.ejphar.2006.05.040
[4] LUCAS GOMES-DE SOUZA . CB1 and CB2 receptors in the bed nucleus of the stria terminalis differently modulate anxiety-like behaviors in rats[J]. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2021, 110: Article 110284. DOI: 10.1016/j.pnpbp.2021.110284

JTE 907 Preparation Products And Raw materials

Raw materials

Preparation Products

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JTE 907 Suppliers

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282089-49-0, JTE 907Related Search:

JTE 907

N-(1,3-BENZODIOXOL-5-YLMETHYL)-1,2-DIHYDRO-7-METHOXY-2-OXO-8-(PENTYLOXY)-3-QUINOLINECARBOXAMIDE

N-(Benzo[d][1,3]dioxol-5-ylMethyl)-7-Methoxy-2-oxo-8-(pentyloxy)-1,2-dihydro-quinolin-3-carboxaMide

N-(benzo[d][1,3]dioxol-5-ylMethyl)-7-Methoxy-2-oxo-8-(pentyl

3-QuinolinecarboxaMide,N-(1,3-benzodioxol-5-ylMethyl)-1,2-dihydro-7-Methoxy-2-oxo-8-(pentyloxy)-

JTE907 (JTE-907

N-(benzo[d][1,3]dioxol-5-ylmethyl)-7-methoxy-2-oxo-8-(pentyloxy)-1,2-dihydroquinoline-3-carboxamide

JTE-907, 10 mM in DMSO

N-(Benzo[d][1,3]dioxol-5-ylmethyl)-2-hydroxy-7-methoxy-8-(pentyloxy)quinoline-3-carboxamide

282089-49-0