YUM70

Product Name: YUM70
CAS No.: 423145-35-1
Chemical Name: YUM70
Synonyms: YUM70;YUM70 ，S6193;YUM70, 10 mM in DMSO;Butanamide, N-[1,3-benzodioxol-5-yl(5-chloro-8-hydroxy-7-quinolinyl)methyl]-;N-(Benzo[d][1,3]dioxol-5-yl(5-chloro-8-hydroxyquinolin-7-yl)methyl)butyramide;N-[Benzo[1，3]dioxol-5-yl-(5-chloro-8-hydroxy-quinolin-7-yl)-methyl]-butyramide;Heat shock proteins,YUM70,HSP,cancer,pancreatic,reticulum,Apoptosis,GRP78,YUM-70,stress-mediated,inhibit,protein,Inhibitor,glucose-regulated,YUM 70,endoplasmic
CBNumber: CB98372287
Molecular Formula: C21H19ClN2O4
Formula Weight: 398.84
MOL File: 423145-35-1.mol

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YUM70 Property

Boiling point:: 661.0±55.0 °C(Predicted)
Density: 1.373±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (250.73 mM; Need ultrasonic)
pka: 14.74±0.46(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1S/C21H19ClN2O4/c1-2-4-18(25)24-19(12-6-7-16-17(9-12)28-11-27-16)14-10-15(22)13-5-3-8-23-20(13)21(14)26/h3,5-10,19,26H,2,4,11H2,1H3,(H,24,25)
InChIKey: BIQMEYCMAGHOEQ-UHFFFAOYSA-N
SMILES: C(NC(C1=CC=C2OCOC2=C1)C1C(O)=C2C(=C(Cl)C=1)C=CC=N2)(=O)CCC

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0148058
Product name: YUM70
Purity: ≥98.0%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0148058
Product name: YUM70
Purity: ≥98.0%
Packaging: 10mg
Price: $580
Updated: 2021/12/16

ChemScene

Product number: CS-0148058
Product name: YUM70
Purity: ≥98.0%
Packaging: 25mg
Price: $1100
Updated: 2021/12/16

ChemScene

Product number: CS-0148058
Product name: YUM70
Purity: ≥98.0%
Packaging: 50mg
Price: $1700
Updated: 2021/12/16

ChemScene

Product number: CS-0148058
Product name: YUM70
Purity: ≥98.0%
Packaging: 100mg
Price: $2500
Updated: 2021/12/16

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YUM70 Chemical Properties,Usage,Production

Uses

YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. YUM70 also has in vivo efficacy in a pancreatic cancer xenograft model[1].

Biological Activity

YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. YUM70 also has in vivo efficacy in a pancreatic cancer xenograft model[1]. YUM70 shows selective cytotoxicity for MIA PaCa-2, PANC-1, BxPC-3 cells (IC50=2.8, 4.5, and 9.6 μM, respectively) over normal pancreatic tissue-derived HPNE cells (IC50>30 μM)[1].YUM70 (5 μM; 24 h) induces endoplasmic reticulum (ER) stress-mediated apoptosis of MIA PaCa-2cells[1]. YUM70 (30 mg/kg; i.p. 5 days a week for 7 weeks) inhibits tumor growth in a MIA PaCa-2 xenograft model[1].YUM70 (15 mg/kg; i.v.) exhibits t1/2 (1.40 h), CL (724.04 mL/h/kg), and Vss (1162.73 mL/kg) in mice[1].YUM70 (30 mg/kg; p.o.) exhibits bioavailability (6.71%), t1/2 (2.74 h), and CL (9230.15 mL/h/kg) in mice[1].

in vivo

YUM70 (30 mg/kg; i.p. 5 days a week for 7 weeks) inhibits tumor growth in a MIA PaCa-2 xenograft model^[1].
YUM70 (15 mg/kg; i.v.) exhibits t_1/2 (1.40 h), CL (724.04 mL/h/kg), and V_ss (1162.73 mL/kg) in mice^[1].
YUM70 (30 mg/kg; p.o.) exhibits bioavailability (6.71%), t_1/2 (2.74 h), and CL (9230.15 mL/h/kg) in mice^[1].

Animal Model:	8-week old female NCr nude mice were injected with MIA PaCa-2 cells^[1]
Dosage:	30 mg/kg
Administration:	I.p. 5 days a week for 7 weeks
Result:	Observed a significant tumor growth delay with no significant change in body weight during the course of treatment.

References

[1]. Samanta S, et, al. The hydroxyquinoline analog YUM70 inhibits GRP78 to induce ER stress-mediated apoptosis in pancreatic cancer. Cancer Res. 2021 Feb 2;canres.1540.2020.

YUM70 Preparation Products And Raw materials

Raw materials

Preparation Products

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YUM70 Suppliers

China 28 United States 4 Global 32

Beijing Biocreative Technology Co., Ltd.

Tel: 15522676233
Email: 3007606172@qq.com
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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
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ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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InvivoChem

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Shandong Jirun Biomedical Technology Co., Ltd.

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Jinan Jiuli Biotechnology Co. , Ltd.

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423145-35-1, YUM70Related Search:

YUM70

Butanamide, N-[1,3-benzodioxol-5-yl(5-chloro-8-hydroxy-7-quinolinyl)methyl]-

Heat shock proteins,YUM70,HSP,cancer,pancreatic,reticulum,Apoptosis,GRP78,YUM-70,stress-mediated,inhibit,protein,Inhibitor,glucose-regulated,YUM 70,endoplasmic

N-(Benzo[d][1,3]dioxol-5-yl(5-chloro-8-hydroxyquinolin-7-yl)methyl)butyramide

N-[Benzo[1，3]dioxol-5-yl-(5-chloro-8-hydroxy-quinolin-7-yl)-methyl]-butyramide

YUM70, 10 mM in DMSO

YUM70 ，S6193

423145-35-1