YUM70
- Product Name
- YUM70
- CAS No.
- 423145-35-1
- Chemical Name
- YUM70
- Synonyms
- YUM70;YUM70, 10 mM in DMSO;Butanamide, N-[1,3-benzodioxol-5-yl(5-chloro-8-hydroxy-7-quinolinyl)methyl]-;N-(Benzo[d][1,3]dioxol-5-yl(5-chloro-8-hydroxyquinolin-7-yl)methyl)butyramide;N-[Benzo[1，3]dioxol-5-yl-(5-chloro-8-hydroxy-quinolin-7-yl)-methyl]-butyramide;Heat shock proteins,YUM70,HSP,cancer,pancreatic,reticulum,Apoptosis,GRP78,YUM-70,stress-mediated,inhibit,protein,Inhibitor,glucose-regulated,YUM 70,endoplasmic
- CBNumber
- CB98372287
- Molecular Formula
- C21H19ClN2O4
- Formula Weight
- 398.84
- MOL File
- 423145-35-1.mol
YUM70 Property
- Boiling point:
- 661.0±55.0 °C(Predicted)
- Density
- 1.373±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 100 mg/mL (250.73 mM; Need ultrasonic)
- pka
- 14.74±0.46(Predicted)
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-0148058
- Product name
- YUM70
- Purity
- ≥98.0%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0148058
- Product name
- YUM70
- Purity
- ≥98.0%
- Packaging
- 10mg
- Price
- $580
- Updated
- 2021/12/16
- Product number
- CS-0148058
- Product name
- YUM70
- Purity
- ≥98.0%
- Packaging
- 25mg
- Price
- $1100
- Updated
- 2021/12/16
- Product number
- CS-0148058
- Product name
- YUM70
- Purity
- ≥98.0%
- Packaging
- 50mg
- Price
- $1700
- Updated
- 2021/12/16
- Product number
- CS-0148058
- Product name
- YUM70
- Purity
- ≥98.0%
- Packaging
- 100mg
- Price
- $2500
- Updated
- 2021/12/16
YUM70 Chemical Properties,Usage,Production
Biological Activity
YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. YUM70 also has in vivo efficacy in a pancreatic cancer xenograft model[1]. YUM70 shows selective cytotoxicity for MIA PaCa-2, PANC-1, BxPC-3 cells (IC50=2.8, 4.5, and 9.6 μM, respectively) over normal pancreatic tissue-derived HPNE cells (IC50>30 μM)[1].YUM70 (5 μM; 24 h) induces endoplasmic reticulum (ER) stress-mediated apoptosis of MIA PaCa-2cells[1]. YUM70 (30 mg/kg; i.p. 5 days a week for 7 weeks) inhibits tumor growth in a MIA PaCa-2 xenograft model[1].YUM70 (15 mg/kg; i.v.) exhibits t1/2 (1.40 h), CL (724.04 mL/h/kg), and Vss (1162.73 mL/kg) in mice[1].YUM70 (30 mg/kg; p.o.) exhibits bioavailability (6.71%), t1/2 (2.74 h), and CL (9230.15 mL/h/kg) in mice[1].
References
[1]. Samanta S, et, al. The hydroxyquinoline analog YUM70 inhibits GRP78 to induce ER stress-mediated apoptosis in pancreatic cancer. Cancer Res. 2021 Feb 2;canres.1540.2020.
YUM70 Preparation Products And Raw materials
Raw materials
Preparation Products
YUM70 Suppliers
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