2-AMINO-3,4,5-TRICHLOROPYRIDINE

2-AMINO-3,4,5-TRICHLOROPYRIDINE Property

Boiling point:

272.7±35.0 °C(Predicted)

Density 

1.634±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

2.02±0.10(Predicted)

Appearance

off-white solid

Safety

RIDADR 

UN2811

HS Code 

2933399990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

2-AMINO-3,4,5-TRICHLOROPYRIDINE Chemical Properties,Usage,Production

Synthesis

General procedure for the synthesis of 3,4,5-trichloropyridin-2-amine from 2-amino-4-chloropyridine: 2-amino-4-chloropyridine (5.0 g, 0.04 mol) was dissolved in concentrated hydrochloric acid (20 mL) and the solution was cooled to 0 °C in an ice bath. Hydrogen peroxide (8.1 mL, 0.08 mol, 32% aqueous solution) was slowly added to the cooled solution, followed by gradual warming of the reaction mixture to room temperature and continuous stirring for 4 hours. Upon completion of the reaction, the mixture was poured into 100 mL of water and the pH was adjusted to 8 (litmus base) by addition of solid sodium carbonate, followed by extraction with ethyl acetate (3 x 50 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, and the filtrate was filtered and concentrated to give a yellow solid product. Finally, purification by ethanol recrystallization afforded 6.3 g (80% yield) of the target compound 3,4,5-trichloropyridin-2-amine as a white solid with a melting point of 160-162 °C.

References

[1] Patent: US6214801, 2001, B1