10-DEBC HYDROCHLORIDE

Product Name: 10-DEBC HYDROCHLORIDE
CAS No.: 201788-90-1
Chemical Name: 10-DEBC HYDROCHLORIDE
Synonyms: aktX;CCG-206734;CCG 206734;10-DEBC HYDROCHLORIDE;10H-Phenoxazine-10-butanaMine,2-chloro-N,N-diethyl-;10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazinehydrochloride
CBNumber: CB9838323
Molecular Formula: C20H25ClN2O
Formula Weight: 344.88
MOL File: 201788-90-1.mol

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10-DEBC HYDROCHLORIDE Property

Melting point:: >178°C (dec.)
Boiling point:: 465.1±45.0 °C(Predicted)
Density: 1.134±0.06 g/cm3(Predicted)
storage temp.: Desiccate at +4°C
form: White crystalline solid.
pka: 10.46±0.25(Predicted)
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 2558
Product name: 10-DEBChydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $151
Updated: 2021/12/16

Tocris

Product number: 2558
Product name: 10-DEBChydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $634
Updated: 2021/12/16

Usbiological

Product number: 254339
Product name: 10-DEBC hydrochloride
Packaging: 10mg
Price: $409
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0001188
Product name: 10-DEBC HYDROCHLORIDE
Purity: 95.00%
Packaging: 1MG
Price: $148.05
Updated: 2021/12/16

AK Scientific

Product number: 9464CW
Product name: 10-Debchydrochloride
Packaging: 5mg
Price: $229
Updated: 2021/12/16

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10-DEBC HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

10-DEBC Hydrochloride is an AKT inhibitor. Study shows that efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine.

Biological Activity

Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μ M), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC 50 ~ 2-6 μ M) and induces apoptosis in rhabdomyosarcoma cells.

10-DEBC HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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10-DEBC HYDROCHLORIDE Suppliers

China 20 Germany 1 United Kingdom 1 United States 5 Global 27

3B Pharmachem (Wuhan) International Co.,Ltd.

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201788-90-1, 10-DEBC HYDROCHLORIDERelated Search:

Phenoxazine 10-DEBC HYDROCHLORIDE

10H-Phenoxazine-10-butanaMine,2-chloro-N,N-diethyl-

10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazinehydrochloride

10-DEBC HYDROCHLORIDE

aktX

CCG 206734

CCG-206734

201788-90-1

C20H25N2OClHCl