1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]-

Product Name: 1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]-
CAS No.: 2446480-97-1
Chemical Name: 1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]-
Synonyms: KSQ-4279;RG-6614;Ksq-2479;USP1-IN-1;RO7623066;KSQ-4279?(Synonyms: USP1-IN-1);6-(4-Cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[4-[1-isopropyl-4-(trifluoromethyl)-2-imidazolyl]benzyl]-1H-pyrazolo[3,4-d]pyrimidine; 6-(4-Cyclopropyl-6-methoxypyrimidin-5-yl)-1-(4-(1-isopropyl-4-(trifluoromethyl)-1H-imidazol-2-yl)benzyl)-1H-pyrazolo[3,4-d]pyrimidine;6-(4-cyclopropyl-6-methoxy-pyrimidin-5-yl)-1-[[4-[1-isopropyl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methyl]pyrazolo[3,4-d]pyrimidine;6-(4-Cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]-1H-pyrazolo[3,4-d]pyrimidine
CBNumber: CB98388015
Molecular Formula: C27H25F3N8O
Formula Weight: 534.54
MOL File: 2446480-97-1.mol

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1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]- Property

Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 80 mg/mL (149.66 mM; Need ultrasonic)
pka: 2.85±0.60(Predicted)
form: Solid
color: White to light yellow
InChIKey: KCBWAFJCKVKYHO-UHFFFAOYSA-N
SMILES: C1(C2=C(OC)N=CN=C2C2CC2)=NC=C2C=NN(CC3=CC=C(C4N(C(C)C)C=C(C(F)(F)F)N=4)C=C3)C2=N1

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Hazard and Precautionary Statements (GHS)

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1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]- Chemical Properties,Usage,Production

Uses

KSQ-4279 (USP1-IN-1) is a potent USP1 inhibitor and a selective PARP1 inhibitor. KSQ-4279 is promising for research of cancers[1].

in vivo

KSQ-4279 shows dose-dependent, robust and durable anti-tumor regression in multiple TNBC and ovarian cancer Patient-derived xenografts (PDXs) with varied genomic status including BRCA1-mutated and -wildtype models^[1].

IC 50

USP1; PARP1

References

[1] Natalie Y L Ngoi, et al. Targeting the DNA damage response beyond poly(ADP-ribose) polymerase inhibitors: novel agents and rational combinations. Curr Opin Oncol. 2022 Sep 1;34(5):559-569. DOI:10.1097/CCO.0000000000000867

1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]- Suppliers

China 66 United States 1 Global 67

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
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2446480-97-1, 1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]-Related Search:

1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]-

KSQ-4279

USP1-IN-1

6-(4-cyclopropyl-6-methoxy-pyrimidin-5-yl)-1-[[4-[1-isopropyl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methyl]pyrazolo[3,4-d]pyrimidine

6-(4-Cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[4-[1-isopropyl-4-(trifluoromethyl)-2-imidazolyl]benzyl]-1H-pyrazolo[3,4-d]pyrimidine

6-(4-Cyclopropyl-6-methoxypyrimidin-5-yl)-1-(4-(1-isopropyl-4-(trifluoromethyl)-1H-imidazol-2-yl)benzyl)-1H-pyrazolo[3,4-d]pyrimidine

KSQ-4279?(Synonyms: USP1-IN-1)

1H-Pyrazolo[3,4-d]pyrimidine,?6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]-KSQ-4279

RO7623066

RG-6614

6-(4-Cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]-1H-pyrazolo[3,4-d]pyrimidine

Ksq-2479

2446480-97-1

C27H25F3N8O