9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE
- Product Name
- 9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE
- CAS No.
- 3519-82-2
- Chemical Name
- 9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE
- Synonyms
- INCA-6;Nsc25996;NFAT Activation Inhibitor III;INCA-6 NFAT Activation Inhibitor III;9,10-[1,2]benzenoanthracene-13,16(9H,10H)-dione;9,10-[1,2]Benzeno-9,10-dihydro-1,4-anthraquinone;9,10-Dihydro-9,10-[1,2]benzeno-1,4-anthraquinone;9,10-[1,2]Benzeno-9,10-dihydroanthracene-1,4-dione;9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE;9,10[1',2']-Benzenoanthracene-1,4-dione, 9,10-dihydro-
- CBNumber
- CB9839254
- Molecular Formula
- C20H12O2
- Formula Weight
- 284.31
- MOL File
- 3519-82-2.mol
9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE Property
- storage temp.
- Store at RT
- solubility
- Soluble in DMSO
- form
- Yellow solid
N-Bromosuccinimide Price
- Product number
- 480403
- Product name
- NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem
- Packaging
- 5mg
- Price
- $187
- Updated
- 2024/03/01
- Product number
- 21812
- Product name
- NFAT Activation Inhibitor III
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 21812
- Product name
- NFAT Activation Inhibitor III
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- 21812
- Product name
- NFAT Activation Inhibitor III
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $270
- Updated
- 2024/03/01
- Product number
- 21812
- Product name
- NFAT Activation Inhibitor III
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $477
- Updated
- 2024/03/01
9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE Chemical Properties,Usage,Production
Description
NFAT activation inhibitor III is a cell-permeant inhibitor of signaling through nuclear factor of activated T cells (NFAT). It binds the substrate recognition site of the phosphatase calcineurin (Kd = 0.8 μM), preventing it from binding and dephosphorylating NFAT. NFAT activation inhibitor III blocks the nuclear import of NFAT in T cells stimulated with ionomycin . It prevents the induced expression of cytokine mRNAs in T cells stimulated with phorbol ester and ionomycin.
Uses
INCA 6 inhibits nuclear factor of activated T cells (NFAT) dephosphorylation and nuclear import, which in turn, interferes with downstream targets of NFAT including induction of cytokine mRNAs.
Definition
ChEBI: LSM-2729 is an anthraquinone.
General Description
A cell-permeable, potent, and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (Kd = 800 nM), disrupts its interaction with NFAT, and completely blocks calcineurin-dependent NFAT dephosphorylation, nuclear import (~40 μM in C1.7W2 T cells), and induction of NFAT-targeted cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling.
Biological Activity
Inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (K d = 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT.
Biochem/physiol Actions
Cell permeable: yes
storage
Store at -20°C
9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE Preparation Products And Raw materials
Raw materials
Preparation Products
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