3-BROMOMETHYL-PYRIDINE-2-CARBONITRILE
- Product Name
- 3-BROMOMETHYL-PYRIDINE-2-CARBONITRILE
- CAS No.
- 116986-13-1
- Chemical Name
- 3-BROMOMETHYL-PYRIDINE-2-CARBONITRILE
- Synonyms
- 3-(broMoMethyl)picolinonitrile;3-BroMoMethyl-2-cyanopyridine, 97%;3-Bromomethylpyridin-2-carbonitrile;3-BROMOMETHYL-PYRIDINE-2-CARBONITRILE;3-(bromomethyl)-2-Pyridinecarbonitrile;2-Pyridinecarbonitrile, 3-(bromomethyl)-
- CBNumber
- CB9842667
- Molecular Formula
- C7H5BrN2
- Formula Weight
- 197.03
- MOL File
- 116986-13-1.mol
3-BROMOMETHYL-PYRIDINE-2-CARBONITRILE Property
- Boiling point:
- 308.2±27.0 °C(Predicted)
- Density
- 1.60±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.23±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- RIDADR
- UN3439
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P311Call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 2766AA
- Product name
- 3-(Bromomethyl)picolinonitrile
- Packaging
- 1g
- Price
- $265
- Updated
- 2021/12/16
- Product number
- FB139549
- Product name
- 3-(Bromomethyl)picolinonitrile
- Packaging
- 2g
- Price
- $306
- Updated
- 2021/12/16
- Product number
- CS-W006515
- Product name
- 3-(Bromomethyl)picolinonitrile
- Packaging
- 5g
- Price
- $421
- Updated
- 2021/12/16
- Product number
- FB139549
- Product name
- 3-(Bromomethyl)picolinonitrile
- Packaging
- 250mg
- Price
- $57.5
- Updated
- 2021/12/16
- Product number
- CS-W006515
- Product name
- 3-(Bromomethyl)picolinonitrile
- Packaging
- 250mg
- Price
- $62
- Updated
- 2021/12/16
3-BROMOMETHYL-PYRIDINE-2-CARBONITRILE Chemical Properties,Usage,Production
Synthesis
20970-75-6
116986-13-1
Example 75: Synthesis of 3-(bromomethyl)pyridine-2-carbonitrile (1) SYNTHESIS STEPS: To a 100 mL round bottom flask was added 2-cyano-3-methylpyridine (2.36 g, 20.0 mmol), N-bromosuccinimide (NBS, 7.82 g, 43.9 mmol), and carbon tetrachloride (CCl4, 50 mL). The reaction mixture was stirred under reflux conditions for 16 hours. After completion of the reaction, the mixture was cooled to room temperature. The solid product was collected by filtration and washed with 50% ethyl acetate/hexane mixture. Subsequently, the solvent was removed by distillation under reduced pressure and the residue was purified by silica gel column chromatography using 30% ethyl acetate/hexane as eluent to give 3-(bromomethyl)pyridine-2-carbonitrile (2.56 g, 65.0% yield). Mass spectrometry analysis (ESI positive ion mode) m/z: calculated values for C7H5BrN2: 196.0, 198.0; measured values: 197.0, 199.0. 1H NMR (300 MHz, CDCl3) δ ppm: 4.64 (s, 2H), 7.54 (dd, J = 8.04, 4.68 Hz, 1H), 7.92 (dd, J = 8.04, 1.61 Hz, 1H), 8.66 (dd, J = 4.75, 1.53 Hz, 1H).
References
[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 13, p. 4735 - 4751
[2] Patent: WO2009/155121, 2009, A2. Location in patent: Page/Page column 126-127
[3] Patent: WO2015/103317, 2015, A1. Location in patent: Page/Page column 184; 185
[4] Patent: US2006/281750, 2006, A1. Location in patent: Page/Page column 26
[5] ACS Medicinal Chemistry Letters, 2011, vol. 2, # 8, p. 559 - 564
3-BROMOMETHYL-PYRIDINE-2-CARBONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-BROMOMETHYL-PYRIDINE-2-CARBONITRILE manufacturers
- Product
- 3-(BroMoMethyl)pyridine-2-carbonitrile 116986-13-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 3-BROMOMETHYL-PYRIDINE-2-CARBONITRILE 116986-13-1
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-13