ChemicalBook > CAS DataBase List > 5-CYANO-2-THIOPHENE CARBALDEHYDE

5-CYANO-2-THIOPHENE CARBALDEHYDE

Product Name: 5-CYANO-2-THIOPHENE CARBALDEHYDE
CAS No.: 21512-16-3
Chemical Name: 5-CYANO-2-THIOPHENE CARBALDEHYDE
Synonyms: 5-Cyanothiophene-2-carbaldehyde;5-Formyl-2-thiophenecarbonitrile;5-CYANO-2-THIOPHENE CARBALDEHYDE;5-Formyl-thiophene-2-carbonitrile;5-Cyanothiophene-2-carboxaldehyde;5-Cyanothiophene-2-carboxyaldehyde;2-Thiophenecarbonitrile, 5-formyl-;5-aldehyde-2-thiophenecarbonitrile;5-Cyanothiophene-2-carboxaldehyde 97%;5-Cyano-2-thiophene carbaldehyde, 95+%
CBNumber: CB9845653
Molecular Formula: C6H3NOS
Formula Weight: 137.16
MOL File: 21512-16-3.mol

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5-CYANO-2-THIOPHENE CARBALDEHYDE Property

Melting point:: 90-95℃
Boiling point:: 130-135 °C(Press: 1.2 Torr)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Solid
color: White
Water Solubility: Slightly soluble in water.

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36
Safety Statements: 26
RIDADR: UN 3439 6.1/PG III
WGK Germany: 3
HazardClass: 6.1
PackingGroup: III
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS012107
Product name: 5-cyano-2-thiophene carbaldehyde
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 100 mg
Price: $179
Updated: 2025/07/31

Sigma-Aldrich

Product number: 738263
Product name: 5-Cyanothiophene-2-carboxaldehyde
Purity: 97%
Packaging: 1g
Price: $82.8
Updated: 2023/06/20

TCI Chemical

Product number: F1133
Product name: 5-Formylthiophene-2-carbonitrile
Purity: >98.0%(GC)
Packaging: 1g
Price: $109
Updated: 2025/07/31

TCI Chemical

Product number: F1133
Product name: 5-Formylthiophene-2-carbonitrile
Purity: >98.0%(GC)
Packaging: 5g
Price: $434
Updated: 2025/07/31

TRC

Product number: C982260
Product name: 5-Cyanothiophene-2-carboxaldehyde
Packaging: 500mg
Price: $90
Updated: 2021/12/16

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5-CYANO-2-THIOPHENE CARBALDEHYDE Chemical Properties,Usage,Production

Uses

5-Cyanothiophene-2-carboxaldehyde is found in caper and may have pest control activity against meloidogyne incognita.

Synthesis

1003-31-2

68-12-2

21512-16-3

Under the protection of inert atmosphere, n-butyllithium (BuLi, 11.7 mL, 29.3 mmol, 2.5 M solution) was slowly added to a mixture containing diisopropylamine (4.1 mL, 29.3 mmol) and tetrahydrofuran (THF, 150 mL), keeping the temperature lower than -70°C. After addition, the reaction mixture was allowed to gradually warm up to room temperature. Subsequently, the mixture was cooled again to -70°C and a THF solution (15 mL) containing 2-cyanothiophene (3.0 g, 26.7 mmol) was slowly added dropwise at this temperature, and stirring was continued at -78°C for 1 hr after completion of the dropwise addition. Maintaining the reaction temperature below -70°C, N,N-dimethylformamide (DMF, 8.2 mL, 106.6 mmol) was added, followed by continued stirring at -78°C for 1.5 hours. Upon completion of the reaction, citric acid (10 g) was added to the mixture and the entire reaction mixture was poured into water. Diethyl ether extraction was carried out with the water phase and the organic phases were combined, dried and concentrated. The crude product was purified by silica gel column chromatography with an eluent gradient of 10-50% heptane/ethyl acetate (EtOAc). The final product was obtained as 5-formyl-2-thiophenecarbonitrile as a solid with a yield of 2.8 g in 76% yield.

References

[1] Patent: WO2011/73298, 2011, A1. Location in patent: Page/Page column 18
[2] Patent: US2008/200535, 2008, A1. Location in patent: Page/Page column 169

5-CYANO-2-THIOPHENE CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-CYANO-2-THIOPHENE CARBALDEHYDE Suppliers

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View Lastest Price from 5-CYANO-2-THIOPHENE CARBALDEHYDE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-CYANO-2-THIOPHENE CARBALDEHYDE 21512-16-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-CYANO-2-THIOPHENE CARBALDEHYDE 21512-16-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 5-CYANO-2-THIOPHENE CARBALDEHYDE 21512-16-3
Price: US $9.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-03

21512-16-3, 5-CYANO-2-THIOPHENE CARBALDEHYDERelated Search:

2-ACETYL-5-CYANOTHIOPHENE 5-CYANO-N-(([(2-FLUOROBENZYL)OXY]IMINO)METHYL)-3-METHYL-4-PHENYL-2-THIOPHENECARBOXAMIDE 5-(bromoacetyl)thiophene-2-carbonitrile 5-CYANO-N-[(METHOXYIMINO)METHYL]-3-METHYL-4-PHENYL-2-THIOPHENECARBOXAMIDE 5-CYANO-4-METHYL-3-PHENYL-2-THIOPHENECARBOXAMIDE 5-CYANO-3,4-DIMETHYLTHIOPHENE-2-CARBOXAMIDE 5-CYANO-3,4-DIPHENYLTHIOPHENE-2-CARBOXAMIDE N-(([(2-CHLORO-6-FLUOROBENZYL)OXY]IMINO)METHYL)-5-CYANO-3-METHYL-4-PHENYL-2-THIOPHENECARBOXAMIDE methyl 5-cyano-3,4-dihydroxythiophene-2-carboxylate 5-CYANO-3-METHYL-N-(([(4-METHYLBENZYL)OXY]IMINO)METHYL)-4-PHENYL-2-THIOPHENECARBOXAMIDE 5-CYANO-N-[(DIMETHYLAMINO)METHYLENE]-3-METHYL-4-PHENYL-2-THIOPHENECARBOXAMIDE N-(([(4-CHLOROBENZYL)OXY]IMINO)METHYL)-5-CYANO-3-METHYL-4-PHENYL-2-THIOPHENECARBOXAMIDE AKOS 90675 AKOS 91695 5-CYANO-3,4-DI(4-METHOXYPHENYL)THIOPHENE-2-CARBOXAMIDE 5-CYANO-2-THIOPHENE CARBALDEHYDE

5-Cyanothiophene-2-carboxaldehyde

5-Cyanothiophene-2-carboxaldehyde 97%

5-Cyano-2-thiophene carbaldehyde, 95+%

5-Formyl-thiophene-2-carbonitrile

5-CYANO-2-THIOPHENE CARBALDEHYDE

5-aldehyde-2-thiophenecarbonitrile

2-Thiophenecarbonitrile, 5-formyl-

5-Cyanothiophene-2-carboxyaldehyde

5-Formyl-2-thiophenecarbonitrile

5-Cyanothiophene-2-carbaldehyde

21512-16-3