ChemicalBook > CAS DataBase List > 1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL

1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL

Product Name
1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL
CAS No.
214147-48-5
Chemical Name
1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL
Synonyms
1-Acetyl-4-aminopiperidine hyd;1-Acetyl-4-aminopiperidine HCl;1-(4-AMino-1-piperidinyl)-ethanone HCl;1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL;1-Acetylpiperidin-4-amine hydrochloride;1-Acetyl-4-aminopiperidine hydrochloride;4-Amino-1-acetylpiperidine hydrochloride;1-Acetylpiperidin-4-amine dihydrochloride;1-(4-Aminopiperidin-1-yl)ethanone hydrochloride;1-(4-Amino-1-piperidinyl)-ethanone hydrochloride
CBNumber
CB9846337
Molecular Formula
C7H15ClN2O
Formula Weight
178.6598
MOL File
214147-48-5.mol
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1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL Property

Melting point:
231-234℃
storage temp. 
Inert atmosphere,Room Temperature
form 
solid
Appearance
White to off-white Solid
Sensitive 
Air Sensitive
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-26-36/37
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
728764
Product name
1-Acetyl-4-aminopiperidine hydrochloride
Purity
96%
Packaging
500mg
Price
$66
Updated
2023/06/20
TRC
Product number
A632993
Product name
1-(4-Aminopiperidin-1-yl)ethanoneHydrochloride
Packaging
500mg
Price
$110
Updated
2021/12/16
Synthonix
Product number
A12232
Product name
4-Amino-1-acetylpiperidinehydrochloride
Purity
95+%
Packaging
10g
Price
$320
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK983576
Product name
1-Acetylpiperidin-4-aminehydrochloride
Purity
98%
Packaging
1g
Price
$174
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK983576
Product name
1-Acetylpiperidin-4-aminehydrochloride
Purity
98%
Packaging
250mg
Price
$69
Updated
2021/12/16
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1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL Chemical Properties,Usage,Production

Synthesis

283167-28-2

214147-48-5

The general procedure for the synthesis of 1-acetyl-4-aminopiperidine hydrochloride from tert-butyl (1-methylpiperidin-4-yl)carbamate was as follows: tert-butyl 1-(1-acetylpiperidin-4-yl)carbamate (7.72 g, 44.24 mmol) was dissolved in 1,4-dioxane (100 mL) and cooled to 0 °C, followed by the dropwise addition of 1.4 M HCl of 1,4- dioxane solution (12.2 mL, 48.7 mmol). Upon completion of the dropwise addition, a white precipitate was observed to be generated and the precipitate was separated by filtration. The resulting precipitate was dissolved in methanol (100 mL), 1,4- dioxane solution (12.2 mL, 48.7 mmol) of 4.0 M HCl was added and the reaction mixture was stirred for 16 hours at room temperature. After that, a 1,4-dioxane solution (6.10 mL, 24.4 mmol) of 4.0 M HCl was added and the reaction mixture was heated to 40 °C with continuous stirring for 1.5 hours. After completion of the reaction, the volatile solvent was removed by distillation under reduced pressure and the resulting white solid was dried at high temperature. 1-Acetyl-4-aminopiperidine hydrochloride (8.60 g, purity about 90%, yield >95%) was finally obtained. The structure of the product was confirmed by 1H NMR (400 MHz, d6-DMSO): δ 8.52-8.23 (m, 3H), 4.39-4.26 (m, 1H), 3.89-3.77 (m, 1H), 3.28-3.14 (m, 1H), 3.11-3.00 (m, 1H), 2.65-2.54 (m, 1H), 1.99 (s, 3H), 1.97-1.86 (m, 2H), 1.54-1.41 (m, 1H), 1.41-1.27 (m, 1H).

References

[1] Patent: WO2016/34675, 2016, A1. Location in patent: Page/Page column 68-69
[2] Patent: WO2016/34673, 2016, A1. Location in patent: Page/Page column 91

1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL Suppliers

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View Lastest Price from 1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL manufacturers

Career Henan Chemical Co
Product
1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL 214147-48-5
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-01

214147-48-5, 1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCLRelated Search:

4-[[(4-CHLOROPHENYL)SULPHONYL]CYCLOPROPYLAMINO]-1-[(2,6-DICHLOROPYRIDIN-4-YL)CARBONYL]PIPERIDINE 4-[[(4-CHLOROPHENYL)SULPHONYL]CYCLOPROPYLAMINO]-1-[(2-FURYL)CARBONYL]PIPERIDINE N-(1-ACETYLPIPERIDIN-4-YL)-4-CHLORO-N-(CYCLOPROPYL)BENZENESULPHONAMIDE 2-[4-[[(4-CHLOROPHENYL)SULPHONYL]CYCLOPROPYLAMINO]PIPERIDIN-1-YL-CARBONYL]PHENOL ACETATE N-(1-ACETYLPIPERIDIN-4-YL)-N-CYCLOPROPYL-2-[(5-CHLOROPYRIDIN-3-YL)OXY]ACETAMIDE 1-(2-CHLOROBENZOYL)-4-[CYCLOPROPYL(PHENYLSULPHONYL)AMINO]PIPERIDINE N-(1-ACETYL-2,3-DIHYDRO-(1H)-INDOL-5-YL)-N-(1-ACETYLPIPERIDIN-4-YL)-4-CHLOROBENZENESULPHONAMIDE N-[2-((1-ACETYLPIPERIDIN-4-YL)CYCLOPROPYLAMINOACETYLTHIO)ETHYL]-2,6-DICHLOROPYRIDINE-4-CARBOXAMIDE 4-[4-[((4-CHLOROPHENYL)SULPHONYL)CYCLOPROPYLAMINO]PIPERIDIN-1-YL]-4-OXOBUTANOIC ACID N-(1-ACETYLPIPERIDIN-4-YL)-4-[(4-CHLOROBENZYL)AMINO]-N-CYCLOPROPYL-4-OXOBUTANAMIDE N-[2-((1-ACETYLPIPERIDIN-4-YL)CYCLOPROPYLAMINOACETYLTHIO)ETHYL]-2-CHLOROBENZAMIDE 4-[CYCLOPROPYL[((3-TRIFLUOROMETHYL)PHENYL)SULPHONYL]AMINO]-1-[(2,6-DICHLOROPYRIDIN-4-YL)CARBONYL]PIPERIDINE 4-[[(4-CHLOROPHENYL)SULPHONYL]CYCLOPROPYLAMINO]-1-(1-OXOPROPYL)PIPERIDINE 4-[CYCLOPROPYL(PHENYLSULPHONYL)AMINO]-1-[(2,6-DICHLOROPYRIDIN-4-YL)CARBONYL]PIPERIDINE 4-[(2-TERT-BUTYL-(1H)-INDOL-5-YL)AMINO]-1-[(2-CHLOROPHENYL)CARBONYL]PIPERIDINE N-(1-ACETYLPIPERIDIN-4-YL)-2,6-DICHLORO-N-(CYCLOPROPYL)PYRIDINE-4-CARBOXAMIDE 4-[[(4-CHLOROPHENYL)SULPHONYL]CYCLOPROPYLAMINO]-1-(1-OXO-(2E)-3-PHENYLPROPENYL)PIPERIDINE N-(1-ACETYLPIPERIDIN-4-YL)-3-CHLORO-N-CYCLOPROPYL-N'-PHENYLUREA

  • 1-Acetyl-4-aminopiperidine HCl
  • 4-Amino-1-acetylpiperidine hydrochloride
  • 1-Acetylpiperidin-4-amine hydrochloride
  • 1-Acetyl-4-aminopiperidine hydrochloride
  • 1-Acetyl-4-aminopiperidine hyd
  • 1-(4-AMino-1-piperidinyl)-ethanone HCl
  • 1-(4-Aminopiperidin-1-yl)ethanone hydrochloride
  • 1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL
  • 1-(4-aminopiperidin-1-yl)ethan-1-one hydrochloride
  • 1-Acetylpiperidin-4-amine dihydrochloride
  • 1-(4-Amino-1-piperidinyl)-ethanone hydrochloride
  • 1-Acetyl-4-aminopiperidine?hydrochloride 97%min
  • 4-Amino-1-acetylpiperidine hydrochloride - [A12232]
  • 214147-48-5