ChemicalBook > CAS DataBase List > N-Acetyl-L-leucine

N-Acetyl-L-leucine

Product Name: N-Acetyl-L-leucine
CAS No.: 1188-21-2
Chemical Name: N-Acetyl-L-leucine
Synonyms: AC-LEU-OH;ACETYL-L-LEUCINE;ACETYL-DL-LEUCINE;Ac-L-Leu-OH;AC-DL-LEU-OH;N-Ac-L-Leu-OH;(S)-N-Acetylleucine;(S)-2-AcetaMido-4-Methylpentanoic acid;AC-LEUCINE;N-ACETYL-DL-LEU
CBNumber: CB9852903
Molecular Formula: C8H15NO3
Formula Weight: 173.21
MOL File: 1188-21-2.mol

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N-Acetyl-L-leucine Property

Melting point:: 187-190 °C(lit.)
alpha: -24.5 º (c=4, MeOH)
Boiling point:: 303.86°C (rough estimate)
Density: 1.1599 (rough estimate)
refractive index: -22 ° (C=5, EtOH)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Ethanol (Slightly), Water (Slightly, Heated)
form: Crystalline Powder
pka: 3.67±0.10(Predicted)
color: White
optical activity: [α]25/D 23±3°, c = 2 in ethanol
Water Solubility: 0.81 g/100 mL (20 ºC)
BRN: 1724849
CAS DataBase Reference: 1188-21-2(CAS DataBase Reference)
NIST Chemistry Reference: L-leucine, n-acetyl-(1188-21-2)
EPA Substance Registry System: L-Leucine, N-acetyl- (1188-21-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25-36-26
WGK Germany: 3
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29241900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 441511
Product name: N-Acetyl-L-leucine
Purity: ReagentPlus , 99%
Packaging: 25g
Price: $110
Updated: 2025/07/31

TCI Chemical

Product number: A0098
Product name: N-Acetyl-L-leucine
Purity: >99.0%(T)
Packaging: 5g
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: A0098
Product name: N-Acetyl-L-leucine
Purity: >99.0%(T)
Packaging: 25g
Price: $86
Updated: 2025/07/31

Usbiological

Product number: 258455
Product name: N-Acetyl-L-leucine
Packaging: 100g
Price: $345
Updated: 2021/12/16

TRC

Product number: A185035
Product name: N-Acetyl-L-(-)-leucine
Packaging: 25g
Price: $350
Updated: 2021/12/16

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N-Acetyl-L-leucine Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

N-Acetyl-L-(-)-leucine is used in the preparation of small molecule inhibitors of anti-apoptotic Bcl-2 family proteins. Also used in the preparation of amphiphilic copolymers involving hydrophobic amino acid and oligopeptide side chains for optical tumor imaging in vivo.

Definition

ChEBI: The N-acetyl derivative of L-leucine.

reaction suitability

reaction type: C-H Activation
reaction type: solution phase peptide synthesis
reagent type: catalyst
reaction type: Peptide Synthesis

in vivo

Levacetylleucine (60 mg/kg, i.v., administration on days 1, 2 and 3 for 15 days) decreases the postural imbalance scores and accelerates the course of postural compensation induced by UL in rats^[3].
Levacetylleucine (100 mg/kg, oral gavage, administration daily for 28 days) attenuates cortical cell death afer traumatic brain injury (TBI) in N-Acetyl-L-leucine-treated TBI mouse cortices^[4].

Animal Model:	Male Sprague-Dawley rats (mean 400±20 g, age 3 months) after chemical UL^[3]
Dosage:	60 mg/kg
Administration:	i.v., 15 days
Result:	Significantly decreased the postural imbalance scores on 7 day and accelerated the course of postural compensation by about 6 days in rats.

Animal Model:	C57/BL6 mice^[4]
Dosage:	100 mg/kg
Administration:	oral gavage, administration daily for 1-28 days
Result:	Did not afect food intake and body weight in mice.

Animal Model:	N-Acetyl-L-leucine-treated TBI mouse cortices^[4]
Dosage:	100 mg/kg
Administration:	oral gavage, administration daily for 28 days
Result:	Prevented cortical cell death which peaks at early time points (day 1) afer TBI in N-Acetyl-L-leucine-treated TBI mouse cortices.

IC 50

Human Endogenous Metabolite

N-Acetyl-L-leucine Preparation Products And Raw materials

Raw materials

Acetic anhydride Methanol Sodium hydroxide L-Leucine

Preparation Products

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N-Acetyl-L-leucine Suppliers

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View Lastest Price from N-Acetyl-L-leucine manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: N-Acetyl-L-leucine 1188-21-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-11-27

WUHAN FORTUNA CHEMICAL CO., LTD

Product: N-Acetyl-L-leucine 1188-21-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 97.5%-102.5%; AJI
Supply Ability: 20 TONS
Release date: 2025-05-22

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Ac-L-Leu-OH 1188-21-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-01-08

1188-21-2, N-Acetyl-L-leucineRelated Search:

N-L-gamma-Glutamyl-L-leucine HIPPURYL-HIS-LEU N-Glycyl-L-leucine ACETYL-D-LEUCINE,N-ALPHA-ACETYL-D-LEUCINE,N-ACETYL-D-LEUCINE,N-ACETYL-L-LEUCINE:AC-D-LEU-OH ACETYL-DL-LEUCINE,N-ALPHA-ACETYL-DL-LEUCINE,N-ACETYL-DL-LEUCINE,ACETYL-DL-LEUCINE, N- N-(3-Indolylacetyl)-L-leucine, Indole-3-acetyl-L-leucine, 99%,INDOLE-3-ACETYL-L-LEUCINE (R)-1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline N-acetyl-L-leucine L-Leucine DL-Leucine THR-VAL-LEU H-PHE-LEU-OH Z-ALA-LEU-OH H-TRP-LEU-OH H-MET-LEU-OH H-HIS-LEU-OH N-CBZ-LEU-LEU METHYL ESTER ACETYL-L-LEUCINE METHYL ESTER,N-ALPHA-ACETYL-L-LEUCINE METHYL ESTER,N-Acetyl-L-leucine methyl ester H-TYR-LEU-OH

AKOS BBS-00004735

ACETYL-DL-LEUCINE, N-

ACETYL-DL-LEUCINE

ACETYL-L-LEUCINE

AC-DL-LEU-OH

AC-LEUCINE

AC-LEU-OH

IFLAB-BB F0777-0821

N-ALPHA-ACETYL-L-LEUCINE

N-ALPHA-ACETYL-DL-LEUCINE

N-ACETYL LEUCINE

N-ACETYL-L-LEUCINE

N-ACETYL-DL-LEU

(S)-N-Acetylleucine

(S)-2-ACETYLAMINO-4-METHYL-PENTANOIC ACID

(2S)-2-(Acetylamino)-4-methylpentanoic acid

N-Acetyl-L-leucine, 99% 25GR

(S)-2-AcetaMido-4-Methylpentanoic acid

N-Acetyl-L-leucine, 99.0%(T)

N-Acetyl-L-leucine ReagentPlus(R), 99%

N-Acetyl-L-leucine Vetec(TM) reagent grade, 98%

N-Acetyl-L(DL)-Leucine

N-ACETYL-L-LEUCINE CRYSTALLINE

N-ACETYLE-L-LEUCINE

N-Acetyl-L-Leu-OH

(2S)-N-ACETYL-L-LEUCINE

Ac-L-Leu-OH

N-Ac-L-Leu-OH

Leucine, N-acetyl-, L-

L-Leucine, N-acetyl-

N-Acetyl-L-lenucine

n-acetyl-l-leucin

N-Ac-DL-Leucine

N-Acetyl-L-leucine,99%

(S)-Ac-2-amino-4-methyl-pentanoic acid

Acetyl-L-leucine≥ 99% (Assay)

N-Acetyl-L-leucine in stock GMP Factory

N-Acetyl-L-leucine &gt

N-Acetyl-L-leucine USP/EP/BP

N-Acetyl-L-Leucine extrapure, 99%

N-Acdtyl-L-Leucine

N-Acetyl-L-leucine, 10 mM in DMSO

Levacetylleucine

<i>N</i>-Acetyl-<sc>L</sc>-leucine

N-Acetyl-L-leucine, 98%

1188-21-2

CH32CHCH2CHNHCOCH3CO2H

CARBOXYLIC ACID

Modified Amino Acids

Amino Acids and Peptides

Biochemicals and Reagents

BioChemical

A - H

Amino Acid Derivatives

Leucine

Peptide Synthesis

Specialty Synthesis

N-Acetyl-Amino acid series