S-Methyl-L-thiocitrulline dihydrochloride

Product Name: S-Methyl-L-thiocitrulline dihydrochloride
CAS No.: 209589-59-3
Chemical Name: S-Methyl-L-thiocitrulline dihydrochloride
Synonyms: S-MTC dihydrochloride;JNZHDSKJUXGYRG-XRIGFGBMSA-N;L-Ornithine, N5-[imino(methylthio)methyl]-, hydrochloride (1:2);(S,E)-2-Amino-5-((amino(methylthio)methylene)amino)pentanoic acid dihydrochloride
CBNumber: CB9853324
Molecular Formula: C7H15N3O2S.2HCl
Formula Weight: 278.2
MOL File: 209589-59-3.mol

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S-Methyl-L-thiocitrulline dihydrochloride Property

storage temp.: Freezer (-20°C)
solubility: DMF: >14 mg/ml; DMSO: >20 mg/ml; Ethanol: >75 mg/ml; PBS pH 7.2: >25 mg/ml
form: White to off-white solid.
color: white to off-white
Water Solubility: water: 50mg/mL

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Safety

HS Code: 29310099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 472804
Product name: S-Methyl-L-thiocitrulline, Dihydrochloride - CAS 209589-59-3 - Calbiochem
Packaging: 10MG
Price: $189
Updated: 2025/07/31

Cayman Chemical

Product number: 80585
Product name: S-methyl-L-Thiocitrulline (hydrochloride)
Purity: ≥97%
Packaging: 5mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 80585
Product name: S-methyl-L-Thiocitrulline (hydrochloride)
Purity: ≥97%
Packaging: 10mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 80585
Product name: S-methyl-L-Thiocitrulline (hydrochloride)
Purity: ≥97%
Packaging: 50mg
Price: $239
Updated: 2024/03/01

Cayman Chemical

Product number: 80585
Product name: S-methyl-L-Thiocitrulline (hydrochloride)
Purity: ≥97%
Packaging: 100mg
Price: $410
Updated: 2024/03/01

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S-Methyl-L-thiocitrulline dihydrochloride Chemical Properties,Usage,Production

Chemical Properties

white to tan amorphous powder

Uses

S-Methyl-L thiocitrulline, Dihydrochloride is a potent inhibitor of NOS1 and NOS3.

Definition

ChEBI: S-methyl-L-Thiocitrulline (hydrochloride) is a L-alpha-amino acid.

Biological Activity

Cell permeable: yes', 'Primary Target
R at neuronal nitric oxide synthase', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 300 nM for r at neuronal nitric oxide synthase

in vivo

S-MTC dihydrochloride (S-methyl-L-thiocitrulline) is a selective neuronal NOS-inhibitor. Following pretreatment with S-MTC dihydrochloride (i.c.v.), the HBO₂-induced antinociception is significantly antagonized. In Experiment #2, different groups of mice are pretreated with naltrexone hydrochloride (NTX) (3.0 mg/kg, i.p.), L-NAME (1.0 μg/mouse, i.c.v.), S-MTC dihydrochloride (1.0 μg/mouse, i.c.v.) or N⁵-(1-iminoethyl)-L-ornithine (L-NIO) (3.0 mg/kg, s.c.) 15-30 min prior to HBO₂ treatment. The antinociceptive effect assessed 90 min after HBO₂ treatment is completely abolished by NTX and L-NAME, antagonized by two-thirds by S-MTC dihydrochloride and largely unaffected by L-NIO (F=25.57, p<0.0001)^[2]. At a dose of 0.3 mg/kg, S-MTC dihydrochloride (SMTC) causes a rise in mean blood pressure (BP). At doses of 1.0, 3.0 and 10 mg/kg, S-MTC dihydrochloride causes falls in heart rate, rises in BP and vasoconstriction in all three vascular beds^[3].

S-Methyl-L-thiocitrulline dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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S-Methyl-L-thiocitrulline dihydrochloride Suppliers

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S-MTC dihydrochloride

JNZHDSKJUXGYRG-XRIGFGBMSA-N

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L-Ornithine, N5-[imino(methylthio)methyl]-, hydrochloride (1:2)

209589-59-3