2,4-Dimethyl-3-pentanone Property

Melting point:

-80 °C (lit.)

Boiling point:

124 °C (lit.)

Density 

0.806 g/mL at 25 °C (lit.)

vapor pressure 

17.89hPa at 25℃

refractive index 

n20/D 1.400(lit.)

Flash point:

60 °F

storage temp. 

Flammables area

form 

Liquid

color 

Clear colorless to yellow

Water Solubility 

insoluble

BRN 

773782

Dielectric constant

17.07

LogP

1.58-1.86 at 23℃

CAS DataBase Reference

565-80-0(CAS DataBase Reference)

NIST Chemistry Reference

3-Pentanone, 2,4-dimethyl-(565-80-0)

EPA Substance Registry System

3-Pentanone, 2,4-dimethyl- (565-80-0)

Safety

Hazard Codes 

F,Xn

Risk Statements 

11-20-2017/11/20

Safety Statements 

9-16-24/25

RIDADR 

UN 1224 3/PG 2

WGK Germany 

1

RTECS 

SA8575500

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29141990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H332Harmful if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

2,4-Dimethyl-3-pentanone Chemical Properties,Usage,Production

Chemical Properties

2,4-Dimethyl-3-pentanone is a colorless liquid with a characteristic odor similar to that of camphor; it is insoluble in water but soluble in organic solvents.

Uses

DiPK has been used in automotive assembly plants as a ketonic solvent for fuel injectors and as a photoinitiator for IV-curable acrylic coatings in optical fiber gratings. The U.S. production ofDnPK was estimated to be,500,000 lb in 2005 according to the 2006 U.S. EPA Inventory Update Reporting database.

Uses

2,4-Dimethyl-3-pentanone is used in an experimental method to measure the equilibrium isotopic fractionation factor (αeq ) for C-bound H positions adjacent to carbonyl group in ketones.It is a carbonyl compound used in an experimental method to measure the equilibrium isotopic fractionation factor (αeq ) for C-bound H positions adjacent to carbonyl group in ketones. Isobutyrone is a very useful synthetic intermediate. It is an intermediate used to prepare α-aryl ketones. It is also used in Grignard reactions.

Uses

2,4-Dimethyl-3-pentanone was used in an experimental method to measure the equilibrium isotopic fractionation factor (α_eq ) for C-bound H positions adjacent to carbonyl group in ketones.

Production Methods

2,4-Dimethyl-3-pentanone is preferably obtained by ketonization of isobutyric acid over a thorium oxide or zirconium oxide catalyst at 430℃.

Definition

ChEBI: 2,4-dimethyl-3-pentanone is a pentanone that is pentan-3-one substituted by methyl groups at positions 2 and 4 respectively. It has a role as a metabolite. It is functionally related to a pentan-3-one.

Synthesis Reference(s)

Tetrahedron Letters, 24, p. 4207, 1983 DOI: 10.1016/S0040-4039(00)88301-X

Purification Methods

Dry the ketone with CaSO4, shake it with chromatographic alumina and fractionally distil it from P2O5 under N2. [Beilstein 1 IV 3334.]