ARV110

Product Name: ARV110
CAS No.: 2222112-77-6
Chemical Name: ARV110
Synonyms: ARV-110;Bavdegalutamide;Bavdegalutamide (ARV-110);Bavdegalutamide (ARV-110) ，S6965;3-Pyridazinecarboxamide, N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]...;prostate,castration-resistant prostate cancer,receptor,ARV 110,androgen,Bavdegalutamide,Androgen Receptor,inhibit,cancer,ARV110,Inhibitor,metastatic;N-(trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)pyridazine-3-carboxamide;N-((1R,4R)-4-(3-chloro-4-cyanophenox y)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopip eridin-3-yl)-6-fluoro-1,3-dioxoisoindoli n-5-yl)piperazin-1-yl)methyl)piperidin-1 -yl)pyridazine-3-carboxamide;3-Pyridazinecarboxamide, N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]-
CBNumber: CB98715291
Molecular Formula: C41H43ClFN9O6
Formula Weight: 812.29
MOL File: 2222112-77-6.mol

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ARV110 Property

Boiling point:: 1074.1±65.0 °C(Predicted)
Density: 1.49±0.1 g/cm3(Predicted)
storage temp.: Store at-20°C, away from moisture
solubility: DMSO : 26.67 mg/mL (32.83 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 80°C)
pka: 10.59±0.40(Predicted)
form: Solid
color: Light yellow to yellow
InChIKey: CLCTZVRHDOAUGJ-SYVGMNBRSA-N
SMILES: C1(C(N[C@@H]2CC[C@@H](OC3=CC=C(C#N)C(Cl)=C3)CC2)=O)=NN=C(N2CCC(CN3CCN(C4C(F)=CC5=C(C=4)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)C=C1

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Hazard and Precautionary Statements (GHS)

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ARV110 Chemical Properties,Usage,Production

Description

ARV-110 is an androgen receptor PROTAC degrader. It promotes ubiquitination and degradation of the androgen receptor.

Characteristics

ARV-110 is a PROteolysis TArgeting Chimera (PROTAC) protein degrader that recruits the cereblon-containing E3 ubiquitin ligase to direct the polyubiquitination and subsequent proteasomal degradation of AR. It selectively degrades wild-type AR and most clinically relevant mutants with low nanomolar potency.

Uses

Bavdegalutamide (ARV-110) is an orally active, specific androgen receptor (AR) PROTAC degrader. Bavdegalutamide promotes ubiquitination and degradation of AR. Bavdegalutamide can be used for the research of prostate cancer (Pink: AR ligand (HY-168299); Blue: E3 ligase ligand (HY-W093272); Black: linker (HY-W091986))[1].

in vivo

Bavdegalutamide (oral gavage; 1 mg/kg; QD) exhibits a greater than 90% AR degradation in vivo. In LNCaP, VCaP and prostate cancer patient derived xenograft (PDX) models, Bavdegalutamide also exhibits significant inhibition of tumor growth and AR signaling^[2].Bavdegalutamide (oral gavage; 3 or 10 mpk; 30 days) demonstrates in vivo efficacy and reduction of AR-target gene expression in a long term, castrate, enzalutamide-resistant VCaP tumor model. The TGI are 70% and 60% for 3 mpk and 10 mpk dosage. Respectively^[2].

References

[1] Taavi Neklesa, et al. ARV-110: An androgen receptor PROTAC degrader for prostate cancer. American Association for Cancer Research. 2018. 78 (13): pp. 5236.
[2] Taavi K Neklesa,et al. ARV-110: an oral androgen receptor PROTAC degrader for prostate cancer. GU ASCO 2019

ARV110 Preparation Products And Raw materials

Raw materials

Preparation Products

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ARV110 Suppliers

China 88 United States 2 Global 90

Medsyn Biotechnology Co., Ltd

Tel: 028-82250492; 15121117545
Fax: QQ 3627337140
Email: viola.liu@medsynbio.cn
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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
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Chengdu Yinchuangyuan Pharmaceutical Technology Co., Ltd

Tel: 18190710352; 18190710352
Email: dy.zhang@increland.com
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Beijing Yisiyan Technology Research Center

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Email: bjkaida@163.com
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Guangzhou Isun Pharmaceutical Co., Ltd

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Fax: 020-39119999
Email: isunpharm@qq.com
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
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Shanghai YuanYe Biotechnology Co., Ltd.

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Email: 3008007409@qq.com
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Shanghai Chaolan Chemical Technology Center

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Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
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Kaixin Chemical (Hong Kong) Limited

Tel: 010-88886666-01 13112345678
Fax: CDXH21@126.com
Email: loyson@tcypharm.com
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View Lastest Price from ARV110 manufacturers

Xi an Biohorlden Industry Trade Co Ltd

Product: ARV110 2222112-77-6
Price: US $0.00-0.00/gram
Min. Order: 1gram
Purity: 98%
Supply Ability: 100
Release date: 2025-04-14

Henan Aochuang Chemical Co.,Ltd.

Product: 3-Pyridazinecarboxamide, N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]... 2222112-77-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

2222112-77-6, ARV110Related Search:

ARCC-4 ARV-771 ARV-825 ARV-471

3-Pyridazinecarboxamide, N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]-

ARV-110

N-((1R,4R)-4-(3-chloro-4-cyanophenox y)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopip eridin-3-yl)-6-fluoro-1,3-dioxoisoindoli n-5-yl)piperazin-1-yl)methyl)piperidin-1 -yl)pyridazine-3-carboxamide

N-(trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)pyridazine-3-carboxamide

Bavdegalutamide

Bavdegalutamide (ARV-110)

3-Pyridazinecarboxamide, N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]...

prostate,castration-resistant prostate cancer,receptor,ARV 110,androgen,Bavdegalutamide,Androgen Receptor,inhibit,cancer,ARV110,Inhibitor,metastatic

Bavdegalutamide (ARV-110) ，S6965

2222112-77-6

C41H43ClFN9O6