(S)-2-(4-Fluorophenyl)pyrrolidine

Product Name: (S)-2-(4-Fluorophenyl)pyrrolidine
CAS No.: 298690-90-1
Chemical Name: (S)-2-(4-Fluorophenyl)pyrrolidine
Synonyms: (S)-2-(4-Fluorophenyl)pyrrolidine;(2S)-2-(4-fluorophenyl)pyrrolidine;Pyrrolidine, 2-(4-fluorophenyl)-, (2S)-;(S)-2-(4-Fluorophenyl)pyrrolidine (S)-2-(4-Fluorophenyl)pyrrolidine
CBNumber: CB9875223
Molecular Formula: C10H12FN
Formula Weight: 165.21
MOL File: 298690-90-1.mol

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(S)-2-(4-Fluorophenyl)pyrrolidine Property

Boiling point:: 235.5±33.0 °C(Predicted)
Density: 1.078±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 9.76±0.10(Predicted)
CAS DataBase Reference: 298690-90-1(CAS DataBase Reference)

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F791780
Product name: (S)-2-(4-Fluorophenyl)pyrrolidine
Packaging: 5mg
Price: $45
Updated: 2021/12/16

TRC

Product number: F791780
Product name: (S)-2-(4-Fluorophenyl)pyrrolidine
Packaging: 50mg
Price: $220
Updated: 2021/12/16

Apolloscientific

Product number: PC201224
Product name: (S)-2-(4-Fluorophenyl)pyrrolidine
Purity: 98%
Packaging: 250mg
Price: $344
Updated: 2021/12/16

Activate Scientific

Product number: AS7889
Product name: (S)-2-(4-Fluorophenyl)pyrrolidine
Purity: 95+% ee
Packaging: 1g
Price: $849
Updated: 2021/12/16

Apolloscientific

Product number: PC201224
Product name: (S)-2-(4-Fluorophenyl)pyrrolidine
Purity: 98%
Packaging: 1g
Price: $857
Updated: 2021/12/16

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(S)-2-(4-Fluorophenyl)pyrrolidine Chemical Properties,Usage,Production

Uses

(S)-2-(4-Fluorophenyl)pyrrolidine is a pyrrole compound and can be used in the synthesis of organic compounds.

Application

(S)-2-(4-Fluorophenyl)pyrrolidine, also known as amide 2-(4-fluorophenyl)-2-pyrrolidinone, is a drug that has been discovered but not yet clinically developed. It is a blocker of the atrial natriuretic peptide receptor.

Synthesis

The mixture of tert-butyl (4-(4-fluorophenyl)-4-oxobutyl)carbamate (0.2 mmol) and trifluoroacetic acid (equiv) in CH2Cl2 was stirred under nitrogen for 3 h. After all the acid and solvent had been removed under vacuum, the obtained substance was transferred to a nitrogen-filled glovebox and dissolved in a mixed solvent of toluene/THF (5:1, 1 mL). Ti(OiPr)4 (0.24 mmol), DABCO (0.04 mmol), Ir-L9 (0.002 mmol) and KI (0.04 mmol) were added subsequently to the above solution. The total solution was made to 3.0 mL. The resulting vial was transferred to an autoclave, which was charged with 50 atm of H2, and stirred at 50 °C for 13 h. The solution was quenched with aqueous sodium bicarbonate solution. The organic phase was concentratedand the metal complex was removed by using a short silica plug to give the (S)-2-(4-Fluorophenyl)pyrrolidine.

(S)-2-(4-Fluorophenyl)pyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-2-(4-Fluorophenyl)pyrrolidine Suppliers

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298690-90-1, (S)-2-(4-Fluorophenyl)pyrrolidineRelated Search:

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(2S)-2-(4-fluorophenyl)pyrrolidine

(S)-2-(4-Fluorophenyl)pyrrolidine (S)-2-(4-Fluorophenyl)pyrrolidine

(S)-2-(4-Fluorophenyl)pyrrolidine

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298690-90-1