tofenacin hydrochloride

Product Name: tofenacin hydrochloride
CAS No.: 10488-36-5
Chemical Name: tofenacin hydrochloride
Synonyms: Elamol;BS 7331;Tofacine;NSC 169432;NSC 113809;Orphenadrine USP RC C;tofenacin hydrochloride;Tofenacine hydrochloride;N-Desmethylorphenadrine Hydrochlori;Orphenadrine Related Compound C (20 mg)
CBNumber: CB9878350
Molecular Formula: C17H21NO.ClH
Formula Weight: 291.82
MOL File: 10488-36-5.mol

More

Less

tofenacin hydrochloride Property

Melting point:: 147-148℃ (ethanol ethyl ether )
solubility: Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Light Beige

More

Less

Safety

HS Code: 2922190900
Toxicity: LD50 in mice (mg/kg): 182 orally, 82 s.c., 58 i.p., 36.5 i.v.; in rats: 72 i.p.; in guinea pigs: 92 s.c. (Funcke)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Usbiological

Product number: 291072
Product name: Tofenacin Hydrochloride
Packaging: 1mg
Price: $460
Updated: 2021/12/16

TRC

Product number: T528500
Product name: TofenacinHydrochlorideSalt
Packaging: 25mg
Price: $1135
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 48975
Product name: TofenacinHClSalt
Packaging: 25mg
Price: $2200
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0076679
Product name: METHYL[2-(2-METHYLBENZHYDRYLOXY)ETHYL]AMINE HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $501.63
Updated: 2021/12/16

More

Less

tofenacin hydrochloride Chemical Properties,Usage,Production

Originator

Elamol,Brocades,UK,1971

Uses

A metabolite of Orphenadrine (O695300). An antidepressant prodrug. Ondansetron USP Related Compound C.

Manufacturing Process

A mixture of 39.5 grams of 2-methylbenzhydrol, 200 ml of β-chloroethanol and 10 ml of concentrated hydrochloric acid is boiled under reflux for 4 hours. After cooling, the reaction mixture is poured into water and extracted with petroleum ether (boiling range 40° to 60°C). The layers are separated and the ethereal solution dried with sodium sulfate. It is then filtered. The filtrate is concentrated by evaporation of the solvent. The residue is distilled under reduced pressure to give 51.0 grams (yield 98%) of β-chloroethyl-2- methylbenzhydryl ether, boiling at 156° to 158°C/2.5 mm. A mixture of 51 grams of β-chloroethyl-2-methylbenzhydryl ether and 35 grams of methylamine in 140 ml of methanol is heated for 6 hours in a closed vessel at a temperature of 125° to 135°C. After cooling, the reaction mixture is poured into water and extracted with petroleum ether (boiling range 40° to 60°C). The ether layer is separated and washed with a 2 N hydrochloric acid solution. The acidic layer is made alkaline and extracted with ether. The ethereal solution is separated and dried with sodium sulfate. After filtration, the solvent is evaporated and the residue distilled under reduced pressure. There is thus obtained 40 grams (yield 80%) of N-methylaminoethyl-2- methylbenzhydrylether boiling at 139° to 143°C/0.7 mm.
The base is dissolved in anhydrous ether, and an ethereal solution of hydrochloric acid is added to form the hydrochloride of N-methylaminoethyl-2- methylbenzhydryl ether. The salt is crystallized from a mixture of ethanol and ether. Yield is 36 grams (78%); melting point 147° to 148°C.

brand name

Tofenacin is INN and BAN.

Therapeutic Function

Psychostimulant

tofenacin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

tofenacin hydrochloride Suppliers

China 10 India 2 South Korea 1 United Kingdom 1 United States 4 Global 18

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9823
Advantage: 79

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131980
Advantage: 58

ChemeGen 中国

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 6975
Advantage: 58

Hunan Zengda Biological Technology Co., LTD

Tel: 18711085600
Email: 1652923704@qq.com
Country: China
ProdList: 4583
Advantage: 58

Shaanxi Dideu Newmaterial Co., Ltd.

Tel: 029-63373950 15353716720
Email: 1052@dideu.com
Country: China
ProdList: 10011
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 11572
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.com
Country: China
ProdList: 24246
Advantage: 58

10488-36-5, tofenacin hydrochlorideRelated Search:

tofenacin hydrochloride 3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene tofenacin ORPHENADRINE HYDROCHLORIDE

tofenacin hydrochloride

BS 7331

Elamol

N-Methyl-2-[(2-methylphenyl)phenylmethoxy]ethanamine hydrochloride

NSC 113809

NSC 169432

Tofacine

Tofenacine hydrochloride

Orphenadrine USP RC C

Orphenadrine Related Compound C (20 mg) (N-methyl-[2-(2-methylbenhydryloxy)ethyl]amine hydrochloride)

N-Desmethylorphenadrine Hydrochlori

Tofenacin HCl (Orphenadrine USP Related Compound C HCl, N-Desmethyl Orphenadrine HCl)

Orphenadrine Impurity 8 (Orphenadrine USP RC C)

Orphenadrine Related Compound C (20 mg)

Orphenadrine Related Compound C (N-methyl-[2-(2-methylbenzhydryloxy)ethyl]amine hydrochloride) (1479031)

Orphenadrine Related Compound C as Hydrochloride

Orphenadrine USP Related Compound C as Hydrochloride

Orphenadrine Related Compound C (20 mg) (N-methyl-2-[phenyl(o-tolyl)methoxy]ethanamine hydrochloride)

10488-36-5