ChemicalBook > CAS DataBase List > BIS(2-BROMOETHYL)AMINE HYDROBROMIDE

BIS(2-BROMOETHYL)AMINE HYDROBROMIDE

Product Name: BIS(2-BROMOETHYL)AMINE HYDROBROMIDE
CAS No.: 43204-63-3
Chemical Name: BIS(2-BROMOETHYL)AMINE HYDROBROMIDE
Synonyms: Trazodone Impurity Y;BIS(2-BROMOETHYL)AMINE HBR;Vortioxetine Impurity 36 HBr;bis(2-bromoethyl)ammonium bromide;Bis(2-bromoethyl)amine hydrobromide;2,2'-Dibromodiethylamine Hydrobromide;Bis(2-bromoethyl)amine·hydrobrominate;Bis(2-bromoethyl)ammonium hydrobromide;2-Bromo-N-(2-bromoethyl)ethanamine HBr;BIS(2-BROMOETHYL)AMINEHYDROBROMICACIDSALT
CBNumber: CB9886344
Molecular Formula: C4H10Br3N
Formula Weight: 311.8409
MOL File: 43204-63-3.mol

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BIS(2-BROMOETHYL)AMINE HYDROBROMIDE Property

Melting point:: 203-205℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D425410
Product name: 2,2''-DibromodiethylamineHydrobromide
Packaging: 1g
Price: $160
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142680
Product name: Bis(2-bromoethyl)amine hydrobromide
Packaging: 500mg
Price: $55
Updated: 2021/12/16

Matrix Scientific

Product number: 076029
Product name: Bis(2-Bromoethyl)amine hydrobromide
Purity: 95+%
Packaging: 1g
Price: $74
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142680
Product name: Bis(2-bromoethyl)amine hydrobromide
Packaging: 1g
Price: $93
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142680
Product name: Bis(2-bromoethyl)amine hydrobromide
Packaging: 2g
Price: $162
Updated: 2021/12/16

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BIS(2-BROMOETHYL)AMINE HYDROBROMIDE Chemical Properties,Usage,Production

Uses

2,2''-Dibromodiethylamine Hydrobromide is used in the synthesis of quinone phosphorodiamidate drugs that target DT-diaphorase, an enzyme that is overexpressed in solid tumors. Also used in the preparation of anti-depressive drugs, in the treatment of major depressive disorders. Trazadone Impurity.

Uses

Bis(2-bromoethyl)amine hydrobromide is used in the synthesis of quinone phosphorodiamidate drugs that target DT-diaphorase, an enzyme that is overexpressed in solid tumors. Also used in the preparat ion of anti-depressive drugs, in the treatment of major depressive disorders. Trazadone Impurity.

Synthesis

111-42-2

43204-63-3

The general procedure for the synthesis of bis(2-bromoethyl)amine hydrobromide from diethanolamine is as follows: 157.5 g (1.5 mol) of diethanolamine is added to a 2-liter three-necked flask equipped with a refluxing or distillation apparatus. 1.35 liters of 48% hydrobromic acid is slowly added with stirring (note: this process is exothermic). The reaction mixture was heated in an oil bath at 180-200°C with a controlled vapor temperature of 122°C until 350 ml of liquid was distilled. Subsequently, the unit was adjusted to reflux and kept for 1 hour. The distillation process was repeated and 465 ml of distillate was collected. The unit was again adjusted to reflux and maintained for 3.75 hours before 400 ml of liquid was distilled. After completion of the reaction, the mixture was cooled and 300 ml of ethyl acetate was added to the residue. The resulting suspension was stirred in an ice bath for 1 hour. The precipitate was collected by filtration and washed with ethyl acetate. A final 367 g of white crystalline product was obtained in 78.5% yield with a melting point of 130-135°C.

References

[1] Patent: US2004/266802, 2004, A1. Location in patent: Page 7-8
[2] Patent: US5233031, 1993, A
[3] Journal of Medicinal Chemistry, 2000, vol. 43, # 16, p. 3157 - 3167
[4] Patent: US2007/259883, 2007, A1. Location in patent: Page/Page column 6; 9

BIS(2-BROMOETHYL)AMINE HYDROBROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BIS(2-BROMOETHYL)AMINE HYDROBROMIDE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: bis(2-bromoethyl)ammonium bromide 43204-63-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Career Henan Chemical Co

Product: BIS(2-BROMOETHYL)AMINE HYDROBROMIDE 43204-63-3
Price: US $1.00/KG
Min. Order: 1g
Purity: 85.0-99.8%
Supply Ability: 20 tons
Release date: 2019-12-18

43204-63-3, BIS(2-BROMOETHYL)AMINE HYDROBROMIDERelated Search:

BIS(DIETHYLAMINO)PHOSPHOROCHLORIDATE BIS-(3,4-DIMETHYL-PHENYL)-AMINE Afatinib Vortioxetine Impurity 37 HCl Vortioxetine Impurity 34 Vortioxetine Impurity 25 Vortioxetine Impurity 35 3,5-dibromo-2,2,6,6-tetramethyl-4-piperidone hydrobromide BIS(2-BROMOETHYL)AMINE HYDROBROMIDE

bis(2-bromoethyl)ammonium bromide

BIS(2-BROMOETHYL)AMINEHYDROBROMICACIDSALT

2-BROMO-N-(2-BROMOETHYL)ETHANAMINE HYDROBROMIDE

Bis(2-bromoethyl)amine·hydrobrominate

Bis(2-bromoethyl)amine hydrobromide

EthanaMine, 2-broMo-N-(2-broMoethyl)-, hydrobroMide

2,2'-Dibromodiethylamine Hydrobromide

Bis(2-bromoethyl)ammonium hydrobromide

Ethanamine, 2-bromo-N-(2-bromoethyl)-, hydrobromide (1:1)

Vortioxetine Impurity 36 HBr (Bis(2-Bromoethyl)amine HBr)

Vortioxetine Impurity 36 HBr

Trazodone Impurity Y

BIS(2-BROMOETHYL)AMINE HBR

BIS(2-BROMOETHYL)AMINE HYDROBROMIDE / 43204-63-3

2-bromo-N-(2-bromoethyl)-Ethanamine hydrobromide (1:1)

2-Bromo-N-(2-bromoethyl)ethanamine HBr

43204-63-3

C4H9Br2NHBr

C4H10Br3N

C4H9Br2NBrH