isometheptene

isometheptene Property

Boiling point:

bp 176-178°; bp7 58-59°

Density 

0.795

vapor pressure 

1.39hPa at 25℃

refractive index 

nD15 1.4472

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

10.78±0.10(Predicted)

form 

Oil

color 

Colourless to Pale Yellow

Water Solubility 

3.06g/L at 25℃

LogP

3.03 at 20℃

EPA Substance Registry System

5-Hepten-2-amine, N,6-dimethyl- (503-01-5)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P501Dispose of contents/container to..…

isometheptene Chemical Properties,Usage,Production

Chemical Properties

Colorless oily liquid. Boiling point 176-178°C, 58-59°C (0.93kPa). Relative density 0.795; refractive index 1.4472 (15℃) Soluble in ethanol, ether, acetone or chloroform, practically insoluble in water. Strongly alkaline, can volatilize with water vapor. Has ammonia odor.

Originator

Octinum,Knoll,US,1948

Uses

ctin (Knoll).

Uses

6-Methylamino-2-methylheptene is an intermediate for the synthesis of Isometheptene Maleate (I821325), which belongs to a group of sympathomimetic amine and shows very little antihypertensive activity. Isometheptene Maleate is used as an antispasmodic drug.

Definition

ChEBI: Isometheptene is a secondary amino compound.

Manufacturing Process

Methyl heptenone dissolved in 75% alcohol is reduced with activated aluminum in the presence of methylamine to give isometheptene.

Therapeutic Function

Muscle relaxant