Propamidine
- Product Name
- Propamidine
- CAS No.
- 104-32-5
- Chemical Name
- Propamidine
- Synonyms
- DAPP;Brolene;propamidine;4,4'-(1,3-Propanediyl)bis(oxy)bisbenzamidine;4,4'-[1,3-Propanediylbis(oxy)]dibenzenecarboximidamide;4,4'-[1,3-Propanediylbis(oxy)]bis(benzenecarbimidamide);4,4'-(1,3-Propanediylbis(oxy))bisbenzenecarboximidamide;BenzenecarboxiMidaMide,4,4'-[1,3-propanediylbis(oxy)]bis-
- CBNumber
- CB9897768
- Molecular Formula
- C17H20N4O2
- Formula Weight
- 312.37
- MOL File
- 104-32-5.mol
Propamidine Property
- Boiling point:
- 497.3±55.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- pka
- 12.75±0.50(Predicted)
N-Bromosuccinimide Price
- Product number
- API0015481
- Product name
- PROPAMIDINE
- Purity
- 95.00%
- Packaging
- 100G
- Price
- $774.9
- Updated
- 2021/12/16
Propamidine Chemical Properties,Usage,Production
Uses
as isethionate.
Definition
ChEBI: A polyether that is the bis(4-guanidinophenyl) ether of propane-1,3-diol. Used (as its isethionate salt) for the treatment of minor eye or eyelid infections, such as conjunctivitis and blepharitis.
Pharmaceutical Applications
A synthetic diamidine formulated as the isethionate or as
dibromopropamidine isethionate for topical administration
to the eye. Resistant clinical isolates of Acanthamoeba
have been identified. It is available over the counter in eye
drops.
Its activity against bacterial pathogens is poor, but it exhibits
specific activity against Acanthamoeba spp. Reduction in
sensitivity of Acanthamoeba during encystation might reflect
changes in drug uptake. It is still recommended for aggressive
treatment of amebic keratitis (in combination with neomycin
or other agents), but is not well tolerated.