betazole

Product Name: betazole
CAS No.: 105-20-4
Chemical Name: betazole
Synonyms: betazole;Ametazole;betazole USP/EP/BP;1H-Pyrazole-3-ethanamine;2-(3-Pyrazolyl)ethanamine;3-(2-Aminoethyl)-1H-pyrazole;2-(1H-pyrazol-5-yl)ethanamine;2-(1H-pyrazol-5-yl)ethan-1-amine;2-(1H-pyrazol-5-yl)ethanamine(SALTDATA: FREE)
CBNumber: CB9898598
Molecular Formula: C5H9N3
Formula Weight: 111.15
MOL File: 105-20-4.mol

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betazole Property

Melting point:: 25°C
Boiling point:: bp0.5 118-123°
Density: 0.9902 (rough estimate)
refractive index: 1.4690 (estimate)
storage temp.: 4°C, protect from light
solubility: DMSO: 250 mg/mL (2249.21 mM)
pka: 14.39±0.10(Predicted)
form: Oil
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: P847045
Product name: 2-(3-Pyrazolyl)ethanamine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: P847045
Product name: 2-(3-Pyrazolyl)ethanamine
Packaging: 100mg
Price: $155
Updated: 2021/12/16

ChemScene

Product number: CS-0013438
Product name: Betazole
Purity: 96.86%
Packaging: 10mg
Price: $270
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009171
Product name: 2-(1H-PYRAZOL-3-YL)-ETHYLAMINE
Purity: 95.00%
Packaging: 1G
Price: $555.45
Updated: 2021/12/16

ChemScene

Product number: CS-0013438
Product name: Betazole
Purity: 96.86%
Packaging: 50mg
Price: $730
Updated: 2021/12/16

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betazole Chemical Properties,Usage,Production

Originator

Histalog,Lilly,US,1953

Definition

ChEBI: Pyrazole in which a hydrogen adjacent to one of the nitrogen atoms is substituted by a 2-aminoethyl group. It is a histamine H2-receptor agonist used clinically to test gastric secretory function.

Manufacturing Process

A solution of 55 grams (1.1 mol) of hydrazine hydrate in 100 ml of methanol was cooled in a water bath and stirred while a solution of 48 grams (0.50 mol) of pure γ-pyrone in 100 ml of methanol was added over a period of about 15 minutes. After the addition was complete, the solution was allowed to stand at room temperature for about 1 hour, and was placed in a 1 liter hydrogenation bomb. 25 ml of liquid ammonia were added cautiously with stirring, followed by about 15 cc of Raney nickel catalyst. The bomb was charged with hydrogen to 1,800 pounds pressure, heated to 90°C and agitated. The quantity of hydrogen required to convert the hydrazone into the desired aminoethylpyrazole was taken up in about 3 hours. The bomb was cooled and opened, and the contents filtered. The filtrate was evaporated under reduced pressure to remove the methanol and the residual liquid was distilled under reduced pressure, whereby there were obtained 44.5 grams (81% yield) of 3-β-aminoethylpyrazole boiling at 118°-123°C at a pressure of 0.5 mm of Hg.

brand name

Histalog (Lilly).

Therapeutic Function

Diagnostic aid (gastric secretion)

betazole Preparation Products And Raw materials

Raw materials

Preparation Products

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betazole Suppliers

China 19 United States 5 Global 24

J & K SCIENTIFIC LTD.

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Aikon International Limited

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Bejing Famous Pharmaceutical Technology Co., Ltd.

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Nanjing Hengbei Chemicals Co., Ltd.

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Shaanxi Dideu Medichem Co. Ltd

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Accela ChemBio Inc.

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Accela ChemBio Co.,Ltd.

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105-20-4, betazoleRelated Search:

2-(4-FLUOROPHENYL)-5-(4-NITROPHENYL)-4,5,6,7-TETRAHYDRO-2H-PYRAZOLO[4,3-C]PYRIDINE 1-BENZYL-5-(1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-1H-PYRAZOL-5-YL)-3-(4-FLUOROBENZYL)-2,4(1H,3H)-PYRIMIDINEDIONE 5-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-4,5,6,7-TETRAHYDRO-2H-PYRAZOLO[4,3-C]PYRIDINE 2-(6-CHLORO-2-PYRIDINYL)-5-(4-NITROPHENYL)-4,5,6,7-TETRAHYDRO-2H-PYRAZOLO[4,3-C]PYRIDINE 11-(3-CHLOROPHENYL)-5,11,12,12A-TETRAHYDROPYRAZOLO[3',4':4,5]PYRIDO[2,1-A]ISOQUINOLIN-8(6H)-ONE 1-(4-CHLOROPHENYL)-5-(1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-1H-PYRAZOL-5-YL)-3-(4-FLUOROBENZYL)-2,4(1H,3H)-PYRIMIDINEDIONE 6-(1H-PYRAZOL-5-YL)-2,3-DIHYDRO-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDIN-5-ONE 11-PHENYL-5,11,12,12A-TETRAHYDROPYRAZOLO[3',4':4,5]PYRIDO[2,1-A]ISOQUINOLIN-8(6H)-ONE 2-(2,4-DIFLUOROPHENYL)-4-METHYL-6-(1H-PYRAZOL-5-YL)-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE 3-(1H-PYRAZOL-5-YL)-4H-PYRIMIDO[2,1-B][1,3]BENZOTHIAZOL-4-ONE 11-(4-CHLOROPHENYL)-5,11,12,12A-TETRAHYDROPYRAZOLO[3',4':4,5]PYRIDO[2,1-A]ISOQUINOLIN-8(6H)-ONE 11-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-5,11,12,12A-TETRAHYDROPYRAZOLO[3',4':4,5]PYRIDO[2,1-A]ISOQUINOLIN-8(6H)-ONE 6-(1H-PYRAZOL-5-YL)-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDIN-5-ONE 2-(4-CHLOROPHENYL)-6-[1-(1,1-DIOXOTETRAHYDRO-1H-1LAMBDA6-THIOPHEN-3-YL)-1H-PYRAZOL-5-YL]-4-METHYL-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE 5-(4-NITROPHENYL)-4,5,6,7-TETRAHYDRO-2H-PYRAZOLO[4,3-C]PYRIDINE 5-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-2-(4-METHYLPHENYL)-4,5,6,7-TETRAHYDRO-2H-PYRAZOLO[4,3-C]PYRIDINE 4-METHYL-6-[1-(4-METHYLPHENYL)-1H-PYRAZOL-5-YL]-2-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE 5-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-2-PHENYL-4,5,6,7-TETRAHYDRO-2H-PYRAZOLO[4,3-C]PYRIDINE

3-(2-Aminoethyl)-1H-pyrazole

2-(1H-pyrazol-5-yl)ethanamine(SALTDATA: FREE)

2-(1H-pyrazol-5-yl)ethanamine

2-(3-Pyrazolyl)ethanamine

betazole

Ametazole

1H-Pyrazole-3-ethanamine

betazole USP/EP/BP

2-(1H-pyrazol-5-yl)ethan-1-amine

105-20-4