chlorthenoxazine
- Product Name
- chlorthenoxazine
- CAS No.
- 132-89-8
- Chemical Name
- chlorthenoxazine
- Synonyms
- Ap 67;Valtorin;Valmorin;Piroxina;Ossazone;Apirazin;chlorthenoxazin;chlorthenoxazine;Chlorethylbenzmethoxazone;Chlorthenoxazine, 10 mM in DMSO
- CBNumber
- CB9899858
- Molecular Formula
- C12H8ClNO
- Formula Weight
- 217.65102
- MOL File
- 132-89-8.mol
chlorthenoxazine Property
- Melting point:
- 146-147° (dec)
- Boiling point:
- 303°C (rough estimate)
- Density
- 1.2414 (rough estimate)
- refractive index
- 1.5500 (estimate)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 12.70±0.40(Predicted)
- color
- White to off-white
chlorthenoxazine Chemical Properties,Usage,Production
Originator
Reugaril ,Farber ,Italy ,1966
Definition
ChEBI: Chlorthenoxazine is a benzoxazine.
Manufacturing Process
A mixture of 4 liters chloroform and 1,050 cc ethanol was saturated with dry hydrogen chloride gas at -5°C to +5°C in a vessel having a net volume of 15 liters and provided with a stirring device, reflux cooler, gas feed line, thermometer and dropping funnel. 455 g acrolein which had been precooled to 0°C were added dropwise to the solution over a period of 1 to 2 hours while maintaining the temperature below +5°C and vigorously stirring. 1,070 g salicylamide and 1,080 g glacial acetic acid were added to the resulting solution of beta-chloropropionaldehyde acetal, thereby forming a suspension which was heated to 60°C while stirring. A clear solution was formed which was maintained at 60°C for an additional hour. The solution was allowed to cool to about 40°C and was then washed with water by passing a strong stream of water under the surface of the chloroform and continuously withdrawing the upper phase. When the water had reached a pH of 3-4, the precipitated reaction product was separated by vacuum filtration. The chloroform phase of the filtrate was evaporated under a weak vacuum and the residue was combined with the precipitate first obtained. The combined products were stirred with 2 liters of a 5% sodium hydroxide solution. The raw reaction product was then washed with water, dried and recrystallized from ethanol. The product had the melting point of 146°C to 147°C (decomposition). The yield was 1,260 g, corresponding to 76% of the theoretical yield.
Therapeutic Function
Antipyretic, Analgesic
chlorthenoxazine Preparation Products And Raw materials
Raw materials
Preparation Products
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