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adenosine N1-oxide

Product Name
adenosine N1-oxide
CAS No.
146-92-9
Chemical Name
adenosine N1-oxide
Synonyms
ANO;1-Oxoadenosine;Adenosine 1-oxide;adenosine N1-oxide;1-Oxylatoadenosine-1-ium;adenosine N(sup 1)-oxide;Adenosine N1-Oxide, ANO;Adenosine N1-oxide, 10 mM in DMSO;Adenosine N1oxide,Adenosine N-1-oxide;6-AMINO-9-[(2R,3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]PURIN-7-IUM-7-OLATE
CBNumber
CB9907548
Molecular Formula
C10H13N5O5
Formula Weight
283.24
MOL File
146-92-9.mol
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adenosine N1-oxide Property

Melting point:
155 °C
Boiling point:
777.4±70.0 °C(Predicted)
Density 
2.15±0.1 g/cm3(Predicted)
pka
13.03±0.70(Predicted)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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adenosine N1-oxide Chemical Properties,Usage,Production

Uses

Adenosine N1-oxide is an oral active anti-inflammatory agent, and can be isolated from royal jelly. Adenosine N1-oxide promotes osteogenic and adipocyte differentiation[1][2].

in vivo

Adenosine N1-oxide (oral administration, 135 mg/kg for three times) reduces the lethality caused by LPS (HY-D1056)-induced endotoxin shock in BALB/c mice[1].

Animal Model:LPS-induced endotoxin shock in BALB/c mice[1]
Dosage:135 mg/kg for three times
Administration:Oral administration
Result:Reduced the lethality caused by LPS (HY-D1056)-induced endotoxin shock in BALB/c mice.

References

[1] Kohno K, et al. Anti-inflammatory effects of adenosine N1-oxide. J Inflamm (Lond). 2015;12(1):2. Published 2015 Jan 20. DOI:10.1186/s12950-014-0045-0
[2] Ohashi E, et al. Adenosine N1-Oxide Exerts Anti-inflammatory Effects through the PI3K/Akt/GSK-3β Signaling Pathway and Promotes Osteogenic and Adipocyte Differentiation. Biol Pharm Bull. 2019;42(6):968-976. DOI:10.1248/bpb.b18-00988

adenosine N1-oxide Preparation Products And Raw materials

Raw materials

Preparation Products

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adenosine N1-oxide Suppliers

China 14 United States 3 Global 17
Zhengzhou GranLen pharmaceutical Technology Co., Ltd.
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0371-85513397
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China
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Alfa Chemistry
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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Shanghai YuanYe Biotechnology Co., Ltd.
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0371-85513397 +86-18610099868
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TargetMol Chemicals Inc.
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Aktin Chemicals, Inc.
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Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
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TargetMol Chemicals Inc.
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Beijing Qinling Pharmaceutical Co., Ltd.
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010-61241352 18901327973
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146-92-9, adenosine N1-oxideRelated Search:

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  • 1-Oxoadenosine
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  • 146-92-9