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isoxsuprine

Product Name
isoxsuprine
CAS No.
395-28-8
Chemical Name
isoxsuprine
Synonyms
lsoxsuprine;isoxysuprine;Isoxsuprine Free Base;Isoxsuprine (base and/or unspecified salts);p-Hydroxy-N-(1-methyl-2-phenoxyethyl)norephedrine;4-[1-hydroxy-2-[1-(phenoxy)propan-2-ylamino]propyl]phenol;4-[1-hydroxy-2-[[1-methyl-2-(phenoxy)ethyl]amino]propyl]phenol;1-(p-Hydroxyphenyl)-2-(1-methyl-2-phenoxyethylamino)-1-propanol;1-(4-Hydroxyphenyl)-2-(1-methyl-2-phenoxyethylamino)-1-propanol;4-Hydroxy-α-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]benzyl alcohol
CBNumber
CB9907922
Molecular Formula
C18H23NO3
Formula Weight
301.39
MOL File
395-28-8.mol
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isoxsuprine Property

Melting point:
102.5-103.5°
Boiling point:
442.51°C (rough estimate)
Density 
1.1412 (rough estimate)
refractive index 
1.5740 (estimate)
pka
9.96±0.26(Predicted)
EPA Substance Registry System
Isoxsuprine (395-28-8)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0016261
Product name
ISOXSUPRINE
Purity
95.00%
Packaging
5MG
Price
$503.55
Updated
2021/12/16
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isoxsuprine Chemical Properties,Usage,Production

Originator

Duvadilan,Duphar,France,1958

Uses

Vasodilator.

Definition

ChEBI: 4-[1-hydroxy-2-(1-phenoxypropan-2-ylamino)propyl]phenol is an alkylbenzene.

Manufacturing Process

To a solution of 30.7 g (0.203 mol) of 1-phenoxy-2-aminopropane in 150 ml of ethanol there was added 31.9 g (0.100 mol) of 1-(4'-benzyloxyphenyl)-2- bromopropanone-1. The mixture was heated to boiling temperature and the solution was then refluxed in a reflux condenser for 3 hours. Most of the ethanol was then distilled off in vacuo, Then to the residue there was addedabout 150 ml of diethyl ether. The hydrogen bromide salt of 1-phenoxy-2- aminopropane was filtered off and washed with diethyl ether.
The collected ethereal filtrates were acidified with 50 ml of 4 N hydrochloric acid and this solution was stirred vigorously. The hydrochloride of 1-(4'- benzyloxyphenyl)-2-(1'-methyl-2-phenoxy-ethylamino)propanone-1 precipitated out, was filtered off, washed with water and then with diethyl ether. Then this substance was dried in vacuo. The yield was 37.7 g, i.e., 89% of the theoretically possible yield, calculated on 1-(4'-benzyloxyphenyl)-2- bromine propanone-1. This substance had a light yellow color and melted at 197 to 198°C, while decomposing.
Then 21.89 g of the hydrochloride salt was dissolved in 600 ml of 80% aqueous ethanol. With the addition of a palladium carbon catalyst, this solution was hydrogenated at room temperature under a hydrogen pressure of about 1.1 atmospheres. After 2 mols hydrogen had been absorbed, the catalyst was filtered off and the filtrate was evaporated in vacuo until crystallization occurred. Then the crystals were dissolved by heating in the smallest possible quantity of water and after cooling, the crystallized substance was filtered off, washed with water and dried in vacuo. The yield was 6.80 g, i.e., 39% of the theoretically possible yield. The resultant product recrystallized from water melted at 203° to 204°C.

brand name

Vasodilan (Apothecon).

Therapeutic Function

Vasodilator

isoxsuprine Preparation Products And Raw materials

Raw materials

Preparation Products

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isoxsuprine Suppliers

ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18042
Advantage
56
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
Advantage
58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
Tel
17691182729 18161915376
Email
1046@dideu.com
Country
China
ProdList
10007
Advantage
58
Bejing Famous Pharmaceutical Technology Co., Ltd.
Tel
13331045123
Email
sales@peking-pharmacy.com
Country
China
ProdList
9994
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24647
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19885
Advantage
58
Shaanxi Didu New Materials Co. Ltd
Tel
+86-89586680 +86-13289823923
Email
1026@dideu.com
Country
China
ProdList
8670
Advantage
58

395-28-8, isoxsuprineRelated Search:


  • lsoxsuprine
  • Benzenemethanol, 4-hydroxy-.alpha.-1-(1-methyl-2-phenoxyethyl)aminoethyl-
  • 1-(p-Hydroxyphenyl)-2-(1-methyl-2-phenoxyethylamino)-1-propanol
  • Benzenemethanol, 4-hydroxy-a-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]- (9CI)
  • Benzyl alcohol, p-hydroxy-a-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]- (6CI, 8CI)
  • erythro-1-(p-Hydroxyphenyl)-2-(a-methyl-b-phenoxyethylamino)propanol
  • p-Hydroxy-a-[1-[(1-methyl-2-phenoxyethyl)-amino]ethyl]benzyl alcohol
  • p-Hydroxy-N-(1-methyl-2-phenoxyethyl)norephedrine
  • Isoxsuprine (base and/or unspecified salts)
  • 1-(4-Hydroxyphenyl)-2-(1-methyl-2-phenoxyethylamino)-1-propanol
  • 4-Hydroxy-α-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]benzyl alcohol
  • p-Hydroxy-α-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]benzyl alcohol
  • 4-[1-hydroxy-2-[[1-methyl-2-(phenoxy)ethyl]amino]propyl]phenol
  • 4-[1-hydroxy-2-[1-(phenoxy)propan-2-ylamino]propyl]phenol
  • Benzenemethanol, 4-hydroxy-α-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-
  • isoxysuprine
  • Isoxsuprine Free Base
  • 395-28-8