[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulphonic acid

Product Name: [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulphonic acid
CAS No.: 50567-35-6
Chemical Name: [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulphonic acid
Synonyms: [(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulfonic acid;[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulphonic acid;Methanesulfonic acid, 1-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]-
CBNumber: CB9909951
Molecular Formula: C13H17N3O4S
Formula Weight: 311.36
MOL File: 50567-35-6.mol

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[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulphonic acid Property

Density: 1.46±0.1 g/cm3(Predicted)
Melting point:: 131-132 °C (decomp)
pka: 1.32±0.50(Predicted)

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Hazard and Precautionary Statements (GHS)

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[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulphonic acid Chemical Properties,Usage,Production

Uses

Metamizol (Methamizole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity[1].

Definition

ChEBI: A pyrazole that is antiipyrine substituted at C-4 by a methyl(sulfomethyl)amino group, the sodium salt of which, metamizole sodium, was widely used as a powerful analgesic and antipyretic, but withdrawn from many markets from the 1970s due to a risk of cau ing risk of causing agranulocytosis.

in vivo

Metamizo (Methamizole; 100 mg/kg; i.p.; once; male Swiss albino mice) causes hepatotoxicity as revealed by an increase in serum alanine aminotransferase (ALT) activity^[1].
Metamizo (100 mg/kg; i.p.; once; male Swiss albino mice) causes a decrease in hepatic glutathione (GSH) contents^[1].

Animal Model:	Male Swiss albino mice (6 weeks old, 25-40 g)^[1]
Dosage:	100 mg/kg
Administration:	Intraperitoneal injection; once
Result:	Increased serum ALT level at 5 hours and the maximum serum ALT levels occurred at 5 hours.

Animal Model:	Male Swiss albino mice (6 weeks old, 25-40 g)^[1]
Dosage:	100 mg/kg
Administration:	Intraperitoneal injection; once
Result:	Induced reduction in hepatic glutathione (GSH) content in mice.

References

[1] Heidari R, et, al. Effects of Enzyme Induction and/or Glutathione Depletion on Methimazole-Induced Hepatotoxicity in Mice and the Protective Role of N-Acetylcysteine. Adv Pharm Bull. 2014;4(1):21-8. DOI:10.5681/apb.2014.004

[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulphonic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulphonic acid Suppliers

China 3 India 2 United States 1 Global 6

Tianjin Kailiqi Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Hubei Rhema Reference Materials Technology Co., Ltd.

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TargetMol Chemicals Inc.

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50567-35-6, [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulphonic acid Related Search:

Dibupyrone tempalgin [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulphonic acid (N-ANTIPYRINYL-N-METHYLAMINO)METHANESULPHONIC ACID CALCIUM SALT Metamizole Sodium Monohydrate Salsocain

[(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulfonic acid

[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulphonic acid

Methanesulfonic acid, 1-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]-

50567-35-6