metomidate

Product Name: metomidate
CAS No.: 5377-20-8
Chemical Name: metomidate
Synonyms: EM-01;Hypnodil;AquacalM;MethoxyMol;metomidate;Methomidate;MethoxyMol R-7315;Etomidate impurity B CRS;Metomidate in acetonitrile;Etomidate Impurity 2 (Etomidate EP Impurity B)
CBNumber: CB9913785
Molecular Formula: C13H14N2O2
Formula Weight: 230.26
MOL File: 5377-20-8.mol

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metomidate Property

Boiling point:: 372.26°C (rough estimate)
Density: 1.13
refractive index: 1.6450 (estimate)
storage temp.: Refrigerator
solubility: Chloroform, Methanol
pka: 4.15±0.23(Predicted)
color: Colourless to Pale Yellow
InChI: InChI=1S/C13H14N2O2/c1-10(11-6-4-3-5-7-11)15-9-14-8-12(15)13(16)17-2/h3-10H,1-2H3
InChIKey: FHFZEKYDSVTYLL-UHFFFAOYSA-N
SMILES: C1N(C(C2=CC=CC=C2)C)C(C(OC)=O)=CN=1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E2503004
Product name: Etomidate impurity B
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: e2503004
Price: $150
Updated: 2024/03/01

TRC

Product number: M338755
Product name: Metomidate
Packaging: 1g
Price: $135
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0016219
Product name: METOMIDATE
Purity: 95.00%
Packaging: 5MG
Price: $502.04
Updated: 2021/12/16

Chemenu

Product number: CM187645
Product name: methyl1-(1-phenylethyl)-1H-imidazole-5-carboxylate
Purity: 95%
Packaging: 250mg
Price: $1683
Updated: 2021/12/16

Crysdot

Product number: CD11108784
Product name: Metomidate
Purity: 95+%
Packaging: 250mg
Price: $1786
Updated: 2021/12/16

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metomidate Chemical Properties,Usage,Production

Chemical Properties

Colourless Hazy Oil

Uses

Metomidate is a the methyl ester analogue of Etomidate (E933300), with sedative and hypnotic properties. Metomidate is mainly used as an anesthetic for veterinary use on its own or in combination with Azaperone (A802200) and other sedatives.

Definition

ChEBI: Methomidate is a member of imidazoles.

Biological Functions

Metomidate, a methyl analog of the anesthetic agent etomidate, is a potent inhibitor of CYP11B1 (11β-hydroxylase) and CYP11B2 (aldosterone synthase), the final two enzymes involved in cortisol and aldosterone synthesis, respectively.

Mechanism of action

Metomidate reduces plasma cortisol and glucose concentrations and increases fish pigmentation, presumably because of increased production of melanocyte-stimulating hormone on the same primary protein as adrenocorticotropic hormone (ACTH). Imidazole anesthetics (e.g., metomidate and etomidate) interrupt cortisol synthesis in mammals by suppressing the enzyme 11-beta-hydroxylase, which is necessary for cortisol production.

Clinical Use

Metomidate can be 11CH3 labeled and used as a positron emission tomography (PET) radiotracer in combination with high-resolution computed tomography (CT) to detect adrenocortical tumors expressing these enzymes.

metomidate Preparation Products And Raw materials

Raw materials

Preparation Products

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metomidate Suppliers

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View Lastest Price from metomidate manufacturers

Xiamen Wonderful Bio Technology Co., Ltd.

Product: metomidate 5377-20-8
Price: US $120.00/KG
Min. Order: 1250KG
Purity: 99.8%
Supply Ability: 330T
Release date: 2023-07-21

5377-20-8, metomidate Related Search:

(R)-(+)-1-(1-PHENYLETHYL)-1H-IMIDAZOLE-5-CARBOXYLIC ACID (S)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid Formamide, N-[(1R)-1-phenylethyl]- S-(-)-EtoMidate Formamide, N-formyl-N-(1-phenylethyl)- 1H-Imidazole-5-carboxylic acid, 1-[(1R)-1-phenylethyl]-, 2,3-dihydroxypropyl ester Etomidate Impurity 1 Etomidate Impurity 7 ethyl (R)-2,3-dihydro-3-(1-phenylethyl)-2-thioxo-1H-imidazole-4-carboxylate methyl (R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylate Dexmedetomidine Etomidate Ethonam propoxate metomidate Metomidate Hydrochloride (+)-METOMIDATE HYDROCHLORIDE Ethonam nitrate

metomidate

1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid methyl ester

Methomidate

3-(1-phenylethyl)imidazole-4-carboxylic acid methyl ester

methyl 3-(1-phenylethyl)imidazole-4-carboxylate

Methyl 3-(1-phenylethyl)imidazole-5-carboxylate

1-(α-Methylbenzyl)iMidazole-5-carboxylic Acid Methyl Ester

AquacalM

Hypnodil

MethoxyMol

MethoxyMol R-7315

Methyl 1-(α-Methylbenzyl)iMidazole-5-carboxylate

Methyl 1-[(1RS)-1-phenylethyl]-1H-imidazole-5-carboxylate

Etomidate impurity B CRS

1H-Imidazole-5-carboxylic acid, 1-(1-phenylethyl)-, methyl ester

Methyl 1-(1-Phenylethyl)-1H-Imidazole-5-Carboxylate

Etomidate Impurity 2 (Etomidate EP Impurity B)

EM-01

Metomidate in acetonitrile

5377-20-8

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals