3-azaspiro[5.5]undecane hydrochloride
- Product Name
- 3-azaspiro[5.5]undecane hydrochloride
- CAS No.
- 1125-01-5
- Chemical Name
- 3-azaspiro[5.5]undecane hydrochloride
- Synonyms
- hydrochloride - [A81406];3-Azaspiro[5.5]undecane HCl;4,4-Pentamethylenepiperidine;4,4-Pentamethylenepiperidine HCl;9-azaspiro[5.5]undecane chloride;3-azaspiro[5.5]undecane hydrochloride
- CBNumber
- CB9923980
- Molecular Formula
- C10H20ClN
- Formula Weight
- 189.7255
- MOL File
- 1125-01-5.mol
3-azaspiro[5.5]undecane hydrochloride Property
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble to 100 mM in water and to 100 mM in DMSO
- form
- Powder
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 019241
- Product name
- 4,4-Pentamethylenepiperidine
- Packaging
- 100mg
- Price
- $403
- Updated
- 2021/12/16
- Product number
- P271760
- Product name
- 4,4-PentamethylenepiperidineHydrochloride
- Packaging
- 1g
- Price
- $970
- Updated
- 2021/12/16
- Product number
- Z3893
- Product name
- 3-Azaspiro[5.5]undecanehydrochloride
- Packaging
- 1g
- Price
- $313
- Updated
- 2021/12/16
- Product number
- FA141590
- Product name
- 3-Azaspiro[5.5]undecane hydrochloride
- Packaging
- 2g
- Price
- $712
- Updated
- 2021/12/16
- Product number
- FA141590
- Product name
- 3-Azaspiro[5.5]undecane hydrochloride
- Packaging
- 1g
- Price
- $418.75
- Updated
- 2021/12/16
3-azaspiro[5.5]undecane hydrochloride Chemical Properties,Usage,Production
Uses
4,4-Pentamethylenepiperidine Hydrochloride is a M2 proton channel blocker. Inhibits influenza virus M2 protein (AM2).
Uses
A M2 proton channel blocker. Inhibits influenza virus M2 protein (AM2).
Synthesis
1130-32-1
1125-01-5
The synthesis of BL-1743 started with 3,3-cyclopentane glutarimide, which was first subjected to a reductive reaction with lithium aluminum hydride (LiAlH4) in tetrahydrofuran (THF) under refluxing conditions to afford 3-azaspiro[5,5]undecane hydrochloride (9), which was followed by treatment with HCl/ethyl ether to obtain the target product in 75% yield (see Scheme 1). Next, model compound BL-1743 was prepared by nucleophilic substitution of compound 9 by 2-methylthio-2-imidazoline.In addition, compound 9 was subjected to reductive amination with different aldehydes in dichloroethane using sodium triacetoxyborohydride (NaBH(OAc)3) and formic acid (HCO2H) as reducing agents to afford derivatives 1-8 in yields ranging from 65% to 95%. The results of activity tests showed that the inhibitory activity of BL-1743 was completely lost at 100 μM concentration after the imidazoline ring was replaced by a hydrophobic substituent or a heterocyclic ring that lacked a hydrogen bond donor (HBD), and the AM2 activity remained >90%. In contrast, inhibitors 7 and 8 containing an imidazole head group showed moderate inhibitory activity, suggesting that the presence of a hydrogen bond donor may be a structural feature necessary for inhibitory activity.
References
[1] Patent: US2010/69420, 2010, A1. Location in patent: Page/Page column 7
3-azaspiro[5.5]undecane hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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