chlormerodrin
- Product Name
- chlormerodrin
- CAS No.
- 62-37-3
- Chemical Name
- chlormerodrin
- Synonyms
- Oricur;Katonil;Merilid;Mercoral;Percapyl;ProMeran;Mercardox;Mercloran;Merculest;Neogidrin
- CBNumber
- CB9941654
- Molecular Formula
- C5H11ClHgN2O2
- Formula Weight
- 367.197
- MOL File
- 62-37-3.mol
chlormerodrin Property
- Melting point:
- 152-153°
- Boiling point:
- 142°C
- form
- solid
Safety
- Toxicity
- LD50 orally in rats: ~82 mg/kg (Goldenthal)
chlormerodrin Chemical Properties,Usage,Production
Originator
Neohydrin,Lakeside,US,1952
Uses
Chlormerodrin is a sulfhydryl blocking agent; using NK cells, particularly CAR-modified NK cells, for producing induced cellular vesicles (ICVs) loaded with chemotherapeutic agent(s) for cancer therapy.
Definition
ChEBI: Chlormerodrin is urea in which one of the hydrogens is substituted by a 3-chloromercury-2-methoxyprop-1-yl group. It was formerly used as a diuretic, but more potent and less toxic drugs are now available. Its radiolabelled ((197)Hg, (203)Hg) forms were used in diagnostic aids in renal imaging and brain scans. It has a role as a diuretic and a diagnostic agent. It is an organomercury compound and a member of ureas.
Manufacturing Process
To a refluxing solution of 100 g of allyl urea and 600 ml of absolute methanol there was added with stirring a suspension of 319 g of mercuric acetate and 600 ml of absolute methanol and 60 ml of glacial acetate acid; complete solution resulted. After 6 hours of refluxing, the solution was cooled and clarified by filtration. To this solution there were added 50 g of sodium chloride and 240 ml of water. After a short time a heavy white precipitate settled out. This precipitate, which was 3-chloromercuri-2-methoxypropylurea, was filtered, washed and dried.
brand name
Mercloran (Parke-Davis); Neohydrin (Marion Merrell Dow).
Therapeutic Function
Diuretic
chlormerodrin Preparation Products And Raw materials
Raw materials
Preparation Products
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