ChemicalBook > CAS DataBase List > 6-Bromo-7-methylimidazo[1,2-a]pyridine
6-Bromo-7-methylimidazo[1,2-a]pyridine
Uses- Product Name
- 6-Bromo-7-methylimidazo[1,2-a]pyridine
- CAS No.
- 116355-18-1
- Chemical Name
- 6-Bromo-7-methylimidazo[1,2-a]pyridine
- Synonyms
- 6-broMo-7-MethylH-iMidazo[1;6-Bromo-7-methylimidazo[1,2-a]pyridine;Imidazo[1,2-a]pyridine, 6-bromo-7-methyl-;6-Bromo-7-methylimidazo[1,2-a]pyridine98%;6-Bromo-7-methylimidazo[1,2-a]pyridine 98%
- CBNumber
- CB9957967
- Molecular Formula
- C8H7BrN2
- Formula Weight
- 211.06
- MOL File
- 116355-18-1.mol
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6-Bromo-7-methylimidazo[1,2-a]pyridine Property
- storage temp.
- 2-8°C
- form
- powder
- color
- Light beige
- InChI
- InChI=1S/C8H7BrN2/c1-6-4-8-10-2-3-11(8)5-7(6)9/h2-5H,1H3
- InChIKey
- TYDYYXQQGZNATK-UHFFFAOYSA-N
- SMILES
- C12=NC=CN1C=C(Br)C(C)=C2
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Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2933599590
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
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N-Bromosuccinimide Price
TRC
- Product number
- B697208
- Product name
- 6-Bromo-7-methylimidazo[1,2-a]pyridine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
TRC
- Product number
- B697208
- Product name
- 6-Bromo-7-methylimidazo[1,2-a]pyridine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR3506
- Product name
- 6-Bromo-7-methylimidazo[1,2-a]pyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $84
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H32-9-0Q
- Product name
- 6-Bromo-7-methylimidazo[1,2-a]pyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR3506
- Product name
- 6-Bromo-7-methylimidazo[1,2-a]pyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $212
- Updated
- 2021/12/16
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6-Bromo-7-methylimidazo[1,2-a]pyridine Chemical Properties,Usage,Production
Uses
6-Bromo-7-methylimidazo[1,2-a]pyridine is used as an intermediate in pharmaceuticals and synthetic materials.
Synthesis
107-20-0
98198-48-2
116355-18-1
A solution of 5-bromo-4-methylpyridin-2-amine (8 g, 42.78 mmol) and chloroacetaldehyde (~50% wt aqueous solution, 27.52 mL, 214 mmol) in ethanol (50 mL) was heated to 100°C under nitrogen protection and reacted for 16 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate (100 mL) and the organic phase was washed sequentially with saturated sodium bicarbonate solution (2 x 50 mL), water (2 x 50 mL) and saturated saline (2 x 100 mL). The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 6-bromo-7-methylimidazo[1,2-a]pyridine (8.5 g, 94% yield) as a brown solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6) and LC-MS: 1H NMR δ 8.93 (s, 1H), 7.85 (s, 1H), 7.57 (d, J = 7.56 Hz, 2H), 2.38 (s, 3H); LC-MS (95%) m/z 211 [C8H7BrN2 + H]+.
References
[1] Patent: WO2013/147711, 2013, A1. Location in patent: Page/Page column 207
[2] Patent: US2014/371199, 2014, A1. Location in patent: Paragraph 0729
[3] Patent: WO2010/108074, 2010, A2. Location in patent: Page/Page column 68-69
6-Bromo-7-methylimidazo[1,2-a]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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