YTX-465

Product Name: YTX-465
CAS No.: 2225824-53-1
Chemical Name: YTX-465
Synonyms: YTX-465;YTX-465, 10 mM in DMSO;YTX-465Chemical Structure;N-(2-{4-[3-(1,3-dimethyl-1H-indazol-6-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}-2-oxoethyl)benzamide;Benzamide, N-[2-[4-[3-(1,3-dimethyl-1H-indazol-6-yl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-2-oxoethyl]-;YTX-465,α-synuclein,YTX465,fatty desaturation,Stearoyl-CoA Desaturase (SCD),Inhibitor,YTX 465,Parkinson’s disease,inhibit,synucleinopathies
CBNumber: CB99636780
Molecular Formula: C25H26N6O3
Formula Weight: 458.51
MOL File: 2225824-53-1.mol

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YTX-465 Property

Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO : 100 mg/mL (218.10 mM; Need ultrasonic)
pka: 13.77±0.46(Predicted)
form: Solid
color: White to off-white
InChIKey: UNYSKYOVUXWBJG-UHFFFAOYSA-N
SMILES: C(NCC(N1CCC(C2ON=C(C3=CC4=C(C=C3)C(C)=NN4C)N=2)CC1)=O)(=O)C1=CC=CC=C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0087587
Product name: YTX-465
Purity: 99.06%
Packaging: 1mg
Price: $286
Updated: 2026/06/04

ChemScene

Product number: CS-0087587
Product name: YTX-465
Purity: 99.06%
Packaging: 5mg
Price: $715
Updated: 2026/06/04

ChemScene

Product number: CS-0087587
Product name: YTX-465
Purity: 99.06%
Packaging: 10mg
Price: $1005
Updated: 2026/06/04

ChemScene

Product number: CS-0087587
Product name: YTX-465
Purity: 99.06%
Packaging: 25mg
Price: $1712
Updated: 2026/06/04

ChemScene

Product number: CS-0087587
Product name: YTX-465
Purity: 99.06%
Packaging: 50mg
Price: $2481
Updated: 2026/06/04

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YTX-465 Chemical Properties,Usage,Production

Uses

YTX-465 is a stearoyl-CoA desaturase (Ole1/SCD) inhibitor. YTX-465 inhibits Ole1 and SCD1 with IC50s of 0.039 μM and 30.4 μM, respectively. YTX-465 can be used in the research of Parkinson’s disease and other synucleinopathies[1].

Biological Activity

YTX-465 is a stearoyl-CoA desaturase (Ole1/SCD) inhibitor. YTX-465 inhibits Ole1 and SCD1 with IC50s of 0.039 μM and 30.4 μM, respectively. YTX-465 can be used in the research of Parkinson's disease and other synucleinopathies[1]. YTX-465 (1-10000 nM) has an EC50 value of 0.013 μM for α-synuclein (α-syn) toxicity rescue[1].YTX-465 (0.05 μM; 0-2 days) rescue the growth of α-Syn-expressing yeast[1].YTX-465 (0, 10, 40, 160, 640, 2500 nM; 4h) increases the level of Ole1 protein in wild-type yeast expressing OLE1 in a concentration-dependent manner, that indicate YTX-465 induce a negative feedback loop[1].YTX-465 (0, 0.03, 0.09, 0.27, 0.81 μM; 6 hours) reduces fatty desaturation in a concentration-dependent manner in wild-type yeast, with a 50% reduction in desaturation at 0.03 μM[1].YTX-465 (0.25 μM; 8 hours) decreases the desaturation index (DI) for all major classes of membrane phospholipids in wild-type yeast[1].

IC 50

Ole1: 0.039 μM (IC₅₀); SCD1: 30.4 μM (IC₅₀)

References

[1]. Vincent BM, et al. Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity. Cell Rep. 2018 Dec 4;25(10):2742-2754.e31.

YTX-465 Preparation Products And Raw materials

Raw materials

Preparation Products

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YTX-465 Suppliers

China 26 United States 2 Global 28

Guangzhou Ruitai Chemical Co., Ltd.

Tel: 18344585702
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WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

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Shanghai Lollane Biological Technology Co.,Ltd.

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Shanghai Beckham Medical Technology Co., Ltd

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Shanghai Haozhixiang Biotechnology Co., Ltd

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Shanghai EFE Biological Technology Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

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TargetMol Chemicals Inc.

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Changzhou Chenhong Biotechnology Co., Ltd.

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2225824-53-1, YTX-465Related Search:

YTX-465

YTX-465Chemical Structure

YTX-465,α-synuclein,YTX465,fatty desaturation,Stearoyl-CoA Desaturase (SCD),Inhibitor,YTX 465,Parkinson’s disease,inhibit,synucleinopathies

Benzamide, N-[2-[4-[3-(1,3-dimethyl-1H-indazol-6-yl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-2-oxoethyl]-

N-(2-{4-[3-(1,3-dimethyl-1H-indazol-6-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}-2-oxoethyl)benzamide

YTX-465, 10 mM in DMSO

2225824-53-1