YTX-465 Property

Density 

1.38±0.1 g/cm3(Predicted)

storage temp. 

4°C, protect from light

solubility 

DMSO : 100 mg/mL (218.10 mM; Need ultrasonic)

pka

13.77±0.46(Predicted)

form 

Solid

color 

White to off-white

Hazard and Precautionary Statements (GHS)

YTX-465 Chemical Properties,Usage,Production

Biological Activity

YTX-465 is a stearoyl-CoA desaturase (Ole1/SCD) inhibitor. YTX-465 inhibits Ole1 and SCD1 with IC50s of 0.039 μM and 30.4 μM, respectively. YTX-465 can be used in the research of Parkinson's disease and other synucleinopathies[1]. YTX-465 (1-10000 nM) has an EC50 value of 0.013 μM for α-synuclein (α-syn) toxicity rescue[1].YTX-465 (0.05 μM; 0-2 days) rescue the growth of α-Syn-expressing yeast[1].YTX-465 (0, 10, 40, 160, 640, 2500 nM; 4h) increases the level of Ole1 protein in wild-type yeast expressing OLE1 in a concentration-dependent manner, that indicate YTX-465 induce a negative feedback loop[1].YTX-465 (0, 0.03, 0.09, 0.27, 0.81 μM; 6 hours) reduces fatty desaturation in a concentration-dependent manner in wild-type yeast, with a 50% reduction in desaturation at 0.03 μM[1].YTX-465 (0.25 μM; 8 hours) decreases the desaturation index (DI) for all major classes of membrane phospholipids in wild-type yeast[1].

References

[1]. Vincent BM, et al. Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity. Cell Rep. 2018 Dec 4;25(10):2742-2754.e31.