ChemicalBook > CAS DataBase List > S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT

S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT

Product Name: S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT
CAS No.: 78950-78-4
Chemical Name: S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT
Synonyms: 3-(dipropylamino)tetralin-5-ol;7-(dipropylamino)tetralin-1-ol;2-(Dipropylamino)tetralin-8-ol;8-OH-DPAT (8-Hydroxy-DPAT) ，S8447;8-Hydroxy-2-(di-n-propylamino)tetralin;S(-)-8-Hydroxy-DPAT hydrobromide solid;7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol;5,6,7,8-Tetrahydro-7-(dipropylamino)naphthalen-1-ol;(+/-)-8-Hydroxy-2-dipropylaminotetralinehydrobromide;1-Naphthalenol,7-(dipropylamino)-5,6,7,8-tetrahydro-
CBNumber: CB9972175
Molecular Formula: C16H25NO
Formula Weight: 247.38
MOL File: 78950-78-4.mol

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S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT Property

Boiling point:: 372.5±42.0 °C(Predicted)
Density: 1.03±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: 150mg/ml in DMSO
form: solid
pka: 10.54±0.40(Predicted)
color: white
optical activity: [α]25/D 67.8° in methanol(lit.)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H141
Product name: S(?)-8-Hydroxy-DPAT hydrobromide
Purity: solid
Packaging: 5mg
Price: $129
Updated: 2022/05/15

Sigma-Aldrich

Product number: H141
Product name: S(?)-8-Hydroxy-DPAT hydrobromide
Purity: solid
Packaging: 25mg
Price: $426
Updated: 2022/05/15

Sigma-Aldrich

Product number: H141
Product name: S(?)-8-Hydroxy-DPAT hydrobromide
Purity: solid
Packaging: 100mg
Price: $1430
Updated: 2022/05/15

TRC

Product number: O415005
Product name: 8-OH-DPAT
Packaging: 100mg
Price: $1200
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BRS0000081
Product name: (+/-)-8-HYDROXY-2-DIPROPYL-AMINOTETRALIN
Purity: 95.00%
Packaging: 100MG
Price: $1723.32
Updated: 2021/12/16

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S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT Chemical Properties,Usage,Production

Uses

8-OH-DPAT, is a potent and selective 5-HT agonist.

Definition

ChEBI: A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively

Hazard

A poison.

Biochem/physiol Actions

Partial 5-HT1A serotonin receptor agonist.

in vivo

8-OH-DPAT (1 mg/kg) normalizes hypolocomotion, significantly increases wakefulness and reduces the duration of REM sleep without effect on the duration of non-REM sleep in the dark period in orexin knockout (KO) mice. 8-OH-DPAT shows no obvious effect on wakefulness or the duration of either REM sleep or non-REM sleep in WT mice. 8-OH-DPAT (1 mg/kg, s.c.) activates 5-HT1A receptor in orexin knockout mice^[3].

IC 50

5-HT_1A Receptor: 8.19 (pIC₅₀); 5-HT₇ Receptor: 466 nM (Ki)

S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT Preparation Products And Raw materials

Raw materials

Preparation Products

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S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT Suppliers

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78950-78-4, S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROTRelated Search:

8-HYDROXY-DPAT HYDROBROMIDE

S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT

(+/-)-8-Hydroxy-2-dipropylaminotetralinehydrobromide

7-(dipropylamino)tetralin-1-ol

8-Hydroxy-2-(di-n-propylamino)tetralin

2-(Dipropylamino)tetralin-8-ol

2-(N,N-Dipropylamino)-1,2,3,4-tetrahydronaphthalen-8-ol

5,6,7,8-Tetrahydro-7-(dipropylamino)naphthalen-1-ol

8-Hydroxy-2-(dipropylamino)-1,2,3,4-tetrahydronaphthalene

3-(dipropylamino)tetralin-5-ol

7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol

S(-)-8-Hydroxy-DPAT hydrobromide solid

1-Naphthalenol,7-(dipropylamino)-5,6,7,8-tetrahydro-

8-OH-DPAT (8-Hydroxy-DPAT) ，S8447

78950-78-4

Serotonin receptor