Ricinelaidicacid CAS#: 540-12-5

Ricinelaidicacid Basic information

Product Name:

Ricinelaidicacid

Synonyms:

(12R,9E)-12-Hydroxy-9-octadecenoic acid
9-trans-12-Hydroxyoctadecenoic acid
9-Octadecenoic acid, 12-hydroxy-, (9E,12R)-

CAS:

540-12-5

MF:

C18H34O3

MW:

298.46

Mol File:

540-12-5.mol

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Ricinelaidicacid Chemical Properties

Melting point:: 51～52 1)
refractive index: －
storage temp.: Store at -20°C
solubility: DMF: 3 mg/ml; DMSO: 2 mg/ml; Ethanol: miscible; PBS (pH 7.2): 2 mg/ml

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Ricinelaidicacid Usage And Synthesis

Uses

Ricinelaidic acid, a 12-hydroxy fatty acid，is a leukotriene B4 (LTB4) receptor antagonist with the Ki of 2 μM in porcine neutrophil membranes. Ricinelaidic acid inhibits chemotaxis and calcium flux induced by LTB4 in isolated human neutrophils (IC50=10 and 7 μM, respectively). Ricinelaidic acid inhibits bronchoconstriction induced by LTB4 in rats[1].

Definition

ChEBI: A straight-chain, 18:1, long-chain fatty acid having a trans- double bond at position 9 and an R-oriented hydroxy group at position 12.

References

[1] Yagaloff KA, et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins Leukot Essent Fatty Acids. 1995;52(5):293-297. DOI:10.1016/0952-3278(95)90029-2

RicinelaidicacidSupplier

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