LY288513
LY288513 Basic information
- Product Name:
- LY288513
- Synonyms:
-
- LY288513
- (4S,5R)-N-(4-Bromophenyl)-3-oxo-4,5-diphenyl-1-pyrazolidinecarboxamide
- 1-Pyrazolidinecarboxamide, N-(4-bromophenyl)-3-oxo-4,5-diphenyl-, (4S,5R)-
- LY-288513,LY288513
- CAS:
- 147523-65-7
- MF:
- C22H18BrN3O2
- MW:
- 436.3
- Mol File:
- 147523-65-7.mol
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LY288513 Chemical Properties
- Melting point:
- 120-122°C
- storage temp.
- Store at +4°C
- solubility
- DMSO (Slightly), Methanol (Very Slightly)
- form
- Solid
- color
- White
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LY288513 Usage And Synthesis
Uses
LY 288513 is a CCK-B antagonist, which blocks the effects of nicotine withdrawal on auditory startle.
Definition
ChEBI: (4S,5R)-N-(4-bromophenyl)-3-oxo-4,5-diphenyl-1-pyrazolidinecarboxamide is a stilbenoid.
Biological Activity
Selective CCK 2 receptor antagonist (IC 50 values are 16 and > 30,000 nM for CCK 2 and CCK 1 respectively). Displays anxiolytic and antipsychotic properties in vivo .
in vivo
LY288513 (3, 10 mg/kg, i.p.; 10, 30 mg/kg, p.o.) produces an anxiolytic-like action in mice[3].
LY288513 (1000 mg/kg, p.o.) potentiates the effects of a CNS depressant, slightly lowered body temperature, and had modest sedative effects only at the highest dose examined[3].
| Animal Model: | Male CD-l mice[3] |
| Dosage: | 3, 10 mg/kg; 10, 30 mg/kg |
| Administration: | I.p.; p.o. |
| Result: | Displayed anxiolytic-like effects in the elevated plusmaze. |
storage
Store at +4°C
LY288513Supplier
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
EMMX Biotechnology LLC
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- 888-539-0666
- info@emmx.com
TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
- marketing@targetmol.com
BOC Sciences
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- info@bocsci.com
TargetMol Chemicals Inc.
- Tel
- 4008200310
- marketing@tsbiochem.com