5-CHLORO-1,6-NAPHTHYRIDINE Chemical Properties

Melting point:

106-107℃

Boiling point:

307.9±22.0 °C(Predicted)

Density 

1.349±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

2.04±0.30(Predicted)

Appearance

Off-white to yellow Solid

CAS DataBase Reference

23616-32-2

Safety Information

HazardClass 

IRRITANT

5-CHLORO-1,6-NAPHTHYRIDINE Usage And Synthesis

Synthesis

General procedure for the synthesis of 5-chloro[1,6]diazanaphthalene from 1,6-naphthopyridin-5(6H)-one: the product of Example 36d (0.250 g, 1.71 mmol) was mixed with phosphorus trichloride (4 mL) and reacted under nitrogen protection at 80 °C for 18.5 hours. Upon completion of the reaction, the volatiles were removed by vacuum distillation. The residue was slurried with ice water and adjusted to pH 7-8 with concentrated ammonium hydroxide solution.5-Chloro[1,6]diazanaphthalene was collected by vacuum filtration, washed with water and dried under vacuum to give a gray solid (0.245 g, 87% yield) of sufficient purity to be used in subsequent separations.

References

[1] Patent: WO2008/133753, 2008, A2. Location in patent: Page/Page column 81

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