Pafenolol
Pafenolol Basic information
- Product Name:
- Pafenolol
- Synonyms:
-
- Pafenolol
- H-138/03
- rac-(R*)-1-(Isopropylamino)-3-[4-[2-(3-isopropylureido)ethyl]phenoxy]-2-propanol
- Urea, N-[2-[4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]ethyl]-N'-(1-methylethyl)-
- CAS:
- 75949-61-0
- MF:
- C18H31N3O3
- MW:
- 337.46
- Mol File:
- 75949-61-0.mol
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Pafenolol Chemical Properties
- Boiling point:
- 551.3±50.0 °C(Predicted)
- Density
- 1.064±0.06 g/cm3(Predicted)
- pka
- 13.90±0.20(Predicted)
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Pafenolol Usage And Synthesis
Uses
Pafenolol is a selectively oral-active β1 adrenergic receptor (β1-adrenergic receptor) antagonist that effectively lowers blood pressure. Pharmacokinetic studies in rats indicate that the absorption of Pafenolol is influenced by gastrointestinal contents, with food intake reducing the bioavailability of Pafenolol in rats. Pafenolol can be used in research related to cardiovascular diseases and asthma[1].
IC 50
Beta-1 adrenergic receptor
References
[1] Sigurdsson J A, et al. Pafenolol, a new β 1-selective blocking agent, in mild hypertension. Result of an inpatient study and a subsequent outpatient follow-up[J]. European journal of clinical pharmacology, 1984, 26: 549-553. DOI:10.1007/BF00543483
PafenololSupplier
TargetMol Chemicals Inc.
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Shanghai Yifei Biotechnology Co. , Ltd.
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TargetMol Chemicals Inc.
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Sangon Biotech (Shanghai) Co.,Ltd.
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- 400-821-026
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