Buquiterine
Buquiterine Basic information
- Product Name:
- Buquiterine
- Synonyms:
-
- Buquiterine
- 2-[(1,1-Dimethylethyl)amino]-6,7-dihydro-9,10-dimethoxy-4H-pyrimido[6,1-a]isoquinolin-4-one
- 4H-Pyrimido[6,1-a]isoquinolin-4-one, 2-[(1,1-dimethylethyl)amino]-6,7-dihydro-9,10-dimethoxy-
- CAS:
- 76536-74-8
- MF:
- C18H23N3O3
- MW:
- 329.39
- Mol File:
- 76536-74-8.mol
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Buquiterine Chemical Properties
- Boiling point:
- 486.3±55.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- pka
- 4.07±0.20(Predicted)
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Buquiterine Usage And Synthesis
Originator
Buquiterine,ZYF Pharm Chemical
Manufacturing Process
A solution of 9,10-dimethoxy-2-chloro-6,7-dihydro-4H-pyrimido[6,1- a]isoquinolin-4-one (3.0 g) and t-butylamine (10 ml) in chloroform (75 ml) is heated under reflux for 16 h. The solvent is evaporated under reduced pressure and the residue triturated with a dilute solution of sodium hydroxide to give a white precipitate of 9,10-dimethoxy-2-t-butylamino-6,7-dihydro-4Hpyrimido[ 6,1-a]isoquinolin-4-one.
Therapeutic Function
Bronchodilator