Tiaprost
Tiaprost Basic information
- Product Name:
- Tiaprost
- Synonyms:
-
- Tiaprost
- 7-[3,5-Dihydroxy-2-[3-hydroxy-4-(3-thienyloxy)-1-butenyl]cyclopentyl]-5-heptenoic acid
- Tiaprost(Iliren)
- (E)-7-[3,5-dihydroxy-2-[(E)-3-hydroxy-4-thiophen-3-yloxybut-1-enyl]cyclopentyl]hept-5-enoic acid
- FYBFDIIAPRHIQS-JRSBLEPXSA-N
- Tiaprost Exclusive
- 5-Heptenoic acid, 7-[3,5-dihydroxy-2-[3-hydroxy-4-(3-thienyloxy)-1-buten-1-yl]cyclopentyl]-
- Iliren
- CAS:
- 71116-82-0
- MF:
- C20H28O6S
- MW:
- 396.5
- Mol File:
- 71116-82-0.mol
Tiaprost Chemical Properties
- Boiling point:
- 613.4±55.0 °C(Predicted)
- Density
- 1.325±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 2 mg/ml
- form
- Liquid
- pka
- 4.79±0.10(Predicted)
- color
- Colorless to light yellow
Tiaprost Usage And Synthesis
Uses
Prostaglandin F2α plays a central role in luteolysis. Tiaprost is a synthetic analog of PGF2α that is used in veterinary medicine as an estrus-synchronizing agent. It has also been used to treat endometritis and to induce parturition.[Cayman Chemical]
Uses
Tiaprost, is a prostaglandin F2α (PGF2α) analogue.
in vivo
Plasma progesterone levels decrease sharply within 12 hours after the initial treatment with Tiaprost and within 24 hours reach levels at about 3.18 nM (1 ng/mL). Over the following days, progesterone levels remain either slightly above (cows 1, 3, 5 and 6) or below (cow 2) 3.18 nM. In cow 4, levels remain for 17 days above 3.18 nM and drop below this level thereafter. At term, all cows show the lowest recorded progesterone levels (1 to 2 nM). Repeated luteolytic treatments with Tiaprost (cows 1 and 2) or estradio1 benzoate (cow 3) has no further influence on individual progesterone levels. Treatment with progesterone-releasing intravaginal device (PRID) does not significantly elevate progesterone plasma levels. Total estrogens in plasma remained in general unchanged[1].
IC 50
PGF2α
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