Ara-C triphosphate
Ara-C triphosphate Basic information
- Product Name:
- Ara-C triphosphate
- Synonyms:
-
- Ara-C triphosphate
- Arabinofuranosylcytosine Triphosphate
- Ara-cytidine-5'-triphosphate (ara-CTP) (aqueous solution)
- ara-Cytidine-5'-triphosphate (ara-CTP)
- 2(1H)-Pyrimidinone, 4-amino-1-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-arabinofuranosyl]-
- Cytarabine triphosphate
- ara-CTP·Na3
- Ara-cytidine-5''-triphosphate (ara-CTP) (aqueous solution), DNA synthesis inhibitor
- CAS:
- 13191-15-6
- MF:
- C9H16N3O14P3
- MW:
- 483.16
- Mol File:
- 13191-15-6.mol
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Ara-C triphosphate Chemical Properties
- Boiling point:
- 849.2±75.0 °C(Predicted)
- Density
- 2.50±0.1 g/cm3(Predicted)
- pka
- 0.97±0.50(Predicted)
- form
- Solid
- color
- White to off-white
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Ara-C triphosphate Usage And Synthesis
Uses
Cytarabine triphosphate (Ara-CTP), an active metabolite of Cytarabine, is a competitive inhibitor of DNA synthesis. Intracellular Cytarabine triphosphate levels can be used to predict chemosensitivity of leukemic blasts to Cytarabine[1].
References
[1] Anderson E, et, al. Intracellular cytarabine triphosphate in circulating blasts post-treatment predicts remission status in patients with acute myeloid leukemia. Exp Hematol. 2019 Jun;74:13-18.e3. DOI:10.1016/j.exphem.2019.04.005
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