AS 183
AS 183 Basic information
- Product Name:
- AS 183
- Synonyms:
-
- AS 183
- 3(2H)-Furanone, 2-hydroxy-2,4-dimethyl-5-(1,3,5,7-tetramethylnonyl)-
- CAS:
- 147317-12-2
- MF:
- C19H34O3
- MW:
- 310.475
- Mol File:
- 147317-12-2.mol
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AS 183 Chemical Properties
- Boiling point:
- 405.6±44.0 °C(Predicted)
- Density
- 0.972±0.06 g/cm3(Predicted)
- pka
- 10.18±0.60(Predicted)
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AS 183 Usage And Synthesis
Uses
AS-183 is an inhibitor of cholesterol acyltransferase (ACAT) (IC50=0.94 μM). AS-183 also inhibits the formation of cholesterol esters in HepG2, CaCo2 and THP-1 cells with IC50 values ??of 18.1, 25.5 and 34.5 μM, respectively. AS-183 can be used in the study of atherosclerosis and hypercholesterolemia[1].
References
[1] Kuroda, et al. AS-183, a novel inhibitor of acyl-CoA: cholesterol acyltransferase produced by Scedosporium sp. SPC-15549. The Journal of Antibiotics 46.8 (1993): 1196-1202. DOI:10.7164/antibiotics.46.1196