Rec 15-2739 Chemical Properties

Boiling point:

688.9±55.0 °C(Predicted)

Density 

1.208±0.06 g/cm3(Predicted)

storage temp. 

4°C, protect from light

pka

14.40±0.40(Predicted)

form 

Solid

color 

White to off-white

Rec 15-2739 Usage And Synthesis

Uses

Upidosin (Rec 15/2739) is an α-1 adrenoceptor (α-1 AR) antagonist. Upidosin shows moderate selectivity for the α-1A AR subtype. Upidosin shows uroselectivity in urethra and prostate with a Kb value of 2-3 nM higher than in ear artery and aorta with a Kb value of 20-100 nM. Upidosin inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptor. Upidosin can be used for the research of urethral obstruction[1].

in vivo

References

[1] Leonardi A, et al. Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15/2739 (SB 216469): role of the alpha-1L adrenoceptor in tissue selectivity, part I. J Pharmacol Exp Ther. 1997 Jun;281(3):1272-83. PMID:9190863
[2] Testa R, et al. Functional antagonistic activity of Rec 15/2739, a novel alpha-1 antagonist selective for the lower urinary tract, on noradrenaline-induced contraction of human prostate and mesenteric artery. J Pharmacol Exp Ther. 1996 Jun;277(3):1237-46. PMID:8667184
[3] Kenny BA, et al. Evaluation of the pharmacological selectivity profile of alpha 1 adrenoceptor antagonists at prostatic alpha 1 adrenoceptors: binding, functional and in vivo studies. Br J Pharmacol. 1996 Jun;118(4):871-8. DOI:10.1111/j.1476-5381.1996.tb15480.x

Rec 15-2739(152735-23-4)Related Product Information

• 2-BENZYLOXYBENZYLAMINE
• 4H-1-Benzopyran-4-one,3-methyl-2-phenyl-(9CI)
• 2-(BENZYLOXY)BENZAMIDE
• Rec 15-2739