clitocine
clitocine Basic information
- Product Name:
- clitocine
- Synonyms:
-
- clitocine
- b-D-RibofuranosylaMine, N-(6-aMino-5-nitro-4-pyriMidinyl)-
- β-D-Ribofuranosylamine, N-(6-amino-5-nitro-4- pyrimidinyl)-
- N-(6-Amino-5-nitro-4-pyrimidinyl)-beta-D-ribofuranosylamine
- N-(6-Amino-5-nitro-4-pyrimidinyl)-β-D-ribofuranosylamine
- N-?(6-?amino-?5-?nitro-?4-?pyrimidinyl)?-β-?D-?Ribofuranosylamine
- CAS:
- 105798-74-1
- MF:
- C9H13N5O6
- MW:
- 287.231
- Mol File:
- 105798-74-1.mol
clitocine Chemical Properties
- form
- Solid
- color
- White to off-white
clitocine Usage And Synthesis
Definition
ChEBI: Clitocine is a N-glycosyl compound.
Biological Activity
Clitocine, an adenosine nucleoside analog derived from mushrooms, is a potent readthrough. As an inhibitor of nonsense mutations, it can induce the production of p53 protein in cells carrying p53 nonsense mutant alleles. It induces apoptosis in multidrug-resistant tumor cells by targeting Mcl-1. Has anticancer activity.
in vitro
Clitocine incorporation into mRNA is required for premature stop codon readthrough activity, and the presence of clitocine at the third position of a premature stop codon is sufficient to promote robust readthrough.
Clitocine (0-0.8 μM ; 24 hours) enhances TRAIL-lethality in in LS411N and SW620 cells. It (0.2μM; 36 hours) significantly potentiates TRAIL-mediated apoptosis.
div>
in vivo
Citocine (0.3-3 mg/kg; sc; five times per week)-induced p53 inhibits CAOV-33 p53-UAA136 tumor growth in a xenograft model.
| nu/nu mice (CAOV-3p53-UAA136 xenograft tumors) | |
| Dosage: | 0.3, 3 mg/kg (or 20 mg/kg once per week) |
| Administration: | Sc; five times per week |
| Result: | CAOV-33 p53-UAA136 tumor growth was inhibited. |
clitocineSupplier
- Tel
- +86057186818502 13588463833
- info@sagechem.com
- Tel
- 86-574-27787657
- info@dearchem.com
- Tel
- 571-89925085
- sales@amadischem.com
- Tel
- 010-60605840 18892239720
- psaitong@jm-bio.com
- Tel
- 13382066392