ACTH (6-24) Chemical Properties

Density 

1.45±0.1 g/cm3(Predicted)

Sequence

His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro

ACTH (6-24) Usage And Synthesis

Uses

ACTH (6-24) (human) (Adrenocorticotropic hormone (6-24)) is an ACTH fragment. ACTH (6-24) (human) is a competitive inhibitor of steroidogenesis induced by ACTH (1-39) and ACTH (5-24) (Kd:13.4 and 3.4 nM). ACTH (6-24) (human) inhibits corticosterone production and cAMP accumulation induced by hPTH 1-34[1][2].

References

[1] Rafferty B, et al. Corticosteroidogenesis and adenosine 3', 5'- monophosphate production by the amino-terminal (1-34) fragment of human parathyroid hormone in rat adrenocortical cells. Endocrinology. 1983 Sep;113(3):1036-42. DOI:10.1210/endo-113-3-1036
[2] Bristow AF, et al. Effects of ACTH (corticotropin) analogues on steroidogenesis and cyclic AMP in rat adrenocortical cells. Evidence for two different steroidogenically responsive receptors. Biochem J. 1980 Feb 15;186(2):599-603. DOI:10.1042/bj1860599

ACTH (6-24)(33512-65-1)Related Product Information

• (D-SER1)-ACTH (1-24) (HUMAN, BOVINE, MOUSE, OVINE, PORCINE, RABBIT, RAT) TRIFLUOROACETATE SALT
• ACTH (3-24) (HUMAN, BOVINE, MOUSE, OVINE, PORCINE, RABBIT, RAT) TRIFLUOROACETATE SALT
• Cosyntropin
• H-SER-PHE-SER-NLE-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO-OH
• ACTH (6-24)