amflutizole Chemical Properties

Boiling point:

332.6±42.0 °C(Predicted)

Density 

1.551±0.06 g/cm3(Predicted)

pka

4.16±0.30(Predicted)

amflutizole Usage And Synthesis

Originator

LY 141894,Eli Lilly

Uses

Suppressant (gout).

Manufacturing Process

To a stirred solution of 3-trifluoromethyl-α-(p-toluenesulfonyloxyimino) benzylcyanide in methanol containing methyl thioglycolate was added dropwise over a 30 min period triethylamine. The reaction mixture was stirred at room temperature for 4 h following complete addition, and then was cooled to 0°C and filtered. The precipitate which was collected was recrystallized from hexane and ethyl acetate to provide methyl 3-(3-trifluoromethylphenyl)- 4-amino-5-isothiazolecarboxylate, melting point 94°-95°C.
A solution of methyl 3-(3-trifluoromethylphenyl)-4-amino-5- isothiazolecarboxylate and potassium hydroxide in methanol was heated at reflux for 6 h. The reaction mixture was then poured into ice containing 12 N aqueous hydrochloric acid. The free acid precipitated from the acidic solution, and after all of the ice had melted, the aqueous acidic mixture was filtered. The precipitate was crystallized from ethanol and water to provide 3-(3- trifluoromethylphenyl)-4-amino-5-isothiazolecarboxylic acid, melting point 179°-180°C. Yield 80%.

Therapeutic Function

Uricosuric

amflutizole(82114-19-0)Related Product Information

• 5-ISOTHIAZOLECARBOXYLIC ACID
• 4-Isothiazolamine(9CI)
• ISOTHIAZOLE-5-CARBALDEHYDE
• 3-Methylisothiazole-5-carboxylic acid
• amflutizole
• 3-(3-(Trifluoromethyl)phenyl)-5-isothiazolecarboxylic acid
• 3-METHYLISOTHIAZOLE