7,8,9,10-TETRAHYDRO-BENZO[A]PYREN-7-OL Chemical Properties

Melting point:

142-144 °C(lit.)

Boiling point:

508.5±19.0 °C(Predicted)

Density 

1.323±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.2 mg/ml

form 

A crystalline solid

pka

14.36±0.20(Predicted)

color 

Light brown to brown

Safety Information

WGK Germany 

3

RTECS 

DJ8304000

MSDS

• Language:English Provider:SigmaAldrich

7,8,9,10-TETRAHYDRO-BENZO[A]PYREN-7-OL Usage And Synthesis

Description

7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol is a benzopyrene derivative that is activated by hepatic cytosol into electrophilic sulfuric acid esters, which are capable of forming covalent DNA adducts and inducing mutations.

Chemical Properties

Yellow Solid

Uses

7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol is a benzopyrene derivative that is activated by hepatic cytosol into electrophilic sulfuric acid esters, which are capable of forming covalent DNA adducts and inducing mutations.[Cayman Chemical]

Uses

7,8,9,10-Tetrahydro-benzo[a]pyren-7-ol is a Benzopyrene (B205800) derivative, activated by hepatic cytosol.

General Description

7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol (7-hydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene), a polycyclic aromatic hydrocarbon (PAH), is a substituted benzopyrene. Its bromination reaction with N-bromosaccharin (NBSac) has been investigated. The sulfotransferase-assisted activation of 7-hydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene to form electrophilic, mutagenic, or tumorigenic sulfuric acid ester metabolite, which binds covalently to DNA and leads to mutation, has been reported.

References

[1] H GLATT. Substance-dependent sex differences in the activation of benzylic alcohols to mutagens by hepatic sulfotransferases of the rat.[J]. Carcinogenesis, 1994, 15 11: 2605-2611. DOI: 10.1093/carcin/15.11.2605
[2] YOUNG-JOON SURH  Steven R T. Sulfotransferase-Mediated Activation of 7,8,9,10-Tetrahydro-7-ol, 7,8-Dihydrodiol, and 7,8,9,10-Tetraol Derivatives of Benzo[a]pyrene[J]. Chemical Research in Toxicology, 1995, 8 5: 693-698. DOI: 10.1021/tx00047a008

7,8,9,10-TETRAHYDRO-BENZO[A]PYREN-7-OL(6272-55-5)Related Product Information

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