PIPERIDINE-1-SULFONYL CHLORIDE Chemical Properties

Boiling point:

120℃ (10 Torr)

Density 

1.308 g/mL at 25 °C

refractive index 

1.4920

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

-8.25±0.20(Predicted)

form 

liquid

color 

Dark brown

Sensitive 

Moisture Sensitive

InChIKey

QQJYAXDCMMXECR-UHFFFAOYSA-N

CAS DataBase Reference

35856-62-3

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3265 8 / PGII

WGK Germany 

3

HazardClass 

8

HazardClass 

IRRITANT

PackingGroup 

Ⅱ

HS Code 

2933399990

PIPERIDINE-1-SULFONYL CHLORIDE Usage And Synthesis

Uses

Piperidine-1-sulfonyl chloride is used as pharmaceutical intermediate.

Synthesis

Example 1: Synthesis of piperidine-1-sulfonyl chloride A mixture of piperidine (100 g, 1.17 mol) and triethylamine (178 g, 1.76 mol) in dichloromethane (500 ml) was slowly added to a solution of sulfuryl chloride (238 g, 1.76 mol) in dichloromethane (500 ml) at 0 °C - 5 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 2 hours. After completion of the reaction, the mixture was quenched by pouring into ice water. The organic layer was separated and washed with distilled water (2 x 5 v/v). The organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure to give an oily residue (151.3 g, 70% yield). The resulting product was characterized by nuclear magnetic resonance hydrogen spectroscopy (H NMR): H NMR (300 MHz, CDCl3) δ = 1.58-1.62 (m, 2H), 1.69-1.83 (m, 4H), 3.31-3.42 (m, 4H).

References

[1] Patent: WO2015/83066, 2015, A1. Location in patent: Page/Page column 11-12
[2] Journal of Fluorine Chemistry, 1982, vol. 20, p. 425 - 438
[3] Patent: WO2005/87721, 2005, A2. Location in patent: Page/Page column 81-82
[4] Archiv der Pharmazie (Weinheim, Germany), 1958, vol. 291, p. 7,11
[5] Bulletin de la Societe Chimique de France, 1936, vol. <5> 3, p. 2143,2146, 2149, 2150

PIPERIDINE-1-SULFONYL CHLORIDE(35856-62-3)Related Product Information

• 3-Hydroxypiperidine hydrochloride
• 1-Aminopiperidine
• 4-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER HCL
• 4-Piperidinyl(1-pyrrolidinyl)Methanone hydrochloride
• Rosin
• Morpholine
• METHYL PIPECOLINATE HYDROCHLORIDE
• piperidin-4-ylMethanesulfonaMide
• Piperidinium acetate
• METHYL 1-(CHLOROSULFONYL)PIPERIDINE-4-CARBOXYLATE
• PIPERIDINE-1-SULFONYL CHLORIDE
• 3,5-DIMETHYLPIPERIDINE-1-SULFONYL CHLORIDE
• 4-(aminocarbonyl)piperidine-1-sulfonyl chloride
• 2,6-dimethylpiperidine-1-sulfonyl chloride
• ETHYL 1-(CHLOROSULFONYL)PIPERIDINE-2-CARBOXYLATE
• OCTAHYDROISOQUINOLINE-2(1H)-SULFONYL CHLORIDE
• 2-METHYLPIPERIDINE-1-SULFONYL CHLORIDE
• 3-METHYLPIPERIDINE-1-SULFONYL CHLORIDE