LAPAQUISTAT
LAPAQUISTAT Basic information
- Product Name:
- LAPAQUISTAT
- Synonyms:
-
- LAPAQUISTAT
- Lapaquistat and Lapaquistat Acetate
- Lapaquistat Acetate
- 2-[1-[2-[1-(3-Acetoxy-2,2-diMethylpropyl)-7-chloro-5(S)-(2,3-diMethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3(R)-yl]acetyl]piperidin-4-yl]acetic acid
- TAK-475
- 1-[[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic acid
- CS-1400
- Lapaquistat Acetate (TAK-475)
- CAS:
- 189060-13-7
- MF:
- C33H41ClN2O9
- MW:
- 645.14
- Product Categories:
-
- Amines
- Chiral Reagents
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 189060-13-7.mol
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LAPAQUISTAT Chemical Properties
- Melting point:
- 194-196℃
- Boiling point:
- 826.4±65.0 °C(Predicted)
- Density
- 1.246±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.66±0.10(Predicted)
- color
- White
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LAPAQUISTAT Usage And Synthesis
Uses
A novel squalene synthase inhibitor. Lapaquistat acetate decreased plasma cholesterol and triglyceride levels, by lowering lipoproteins containing apoB100. Treatment with Lapaquistat acetate increased collagen concentration and transformed coronary plaques into fibromuscular plaques. Lapaquistat acetate also suppressed the expression of matrix metalloproteinase-1 and plasminogen activator inhibitor-1 in the plaque and increased peripheral coenzyme Q10 levels.Antiarteriosclerotics.
LAPAQUISTATSupplier
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