6-bromoimidazo[1,2-a]pyrazin-8-amine Chemical Properties

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

Appearance

Yellow to brown Solid

Safety Information

HS Code 

2933998090

6-bromoimidazo[1,2-a]pyrazin-8-amine Usage And Synthesis

Application

6-bromoimidazo[1,2-a]pyrazin-8-amine are a type of synthetic building block with strong pharmacological activity among nitrogen-containing heterocyclic compounds. Heterocyclic compounds are a class of small molecule compounds with strong biological activity and are widely used in fields such as biomedicine, pesticides, and optoelectronic materials. In particular, 6-haloimidazo[1,2-A]pyrazine active small molecule compounds are a research hotspot for major pharmaceutical companies.

Synthesis

General procedure for the synthesis of 6-bromoimidazo[1,2-A]pyrazin-8-amine from 6,8-dibromo-imidazo[1,2-A]pyrazine: The product obtained from the preparation of Example 29 (1.80 g, 6.45 mmol) was mixed with concentrated aqueous NH4OH solution (27.0 mL) in a closed pressure vessel and reacted with stirring for 24 hrs at 90 °C. Upon completion of the reaction, the solvent was removed by evaporation and the resulting residue was purified by silica gel column chromatography with EtOAc as eluent. A white solid product (1.01 g, 73% yield) was finally obtained.LCMS analysis showed that MH+ = 213.

References

[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 18, p. 3353 - 3358
[2] Patent: US2004/63715, 2004, A1. Location in patent: Page/Page column 27
[3] Patent: WO2004/22562, 2004, A1. Location in patent: Page 28

6-bromoimidazo[1,2-a]pyrazin-8-amine(117718-84-0)Related Product Information

• 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE
• 6-BROMOIMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE
• methyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate
• 6-Bromo-imidazo[1,2-a]pyrimidine
• Ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate
• 6-BROMO-THIAZOLO[5,4-B]PYRIDINE
• 6-Bromoimidazo[1,2-b]pyri...
• 6-BROMOTHIAZOLO[5,4-B]PYRAZINE
• 6-bromoH-imidazo[1,2-a]pyridine-2-carboxylic acid
• 6-Bromoimidazo[1,2-a]pyridine
• 6-BROMO-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXALDEHYDE
• 6-Bromo-2-mercaptothiazolo[4,5-b]pyridine
• 6-BROMOIMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID
• Thiazolo[4,5-b]pyridin-2-aMine, 6-broMo-
• Imidazo[1,2-a]pyrazin-8-amine (9CI)
• 6-Bromoimidazo[1,2-a]pyrazine
• 6-BROMO-8-MORPHOLINOIMIDAZOL[1,2-A]PYRAZINE
• IMIDAZO[1,2-A]PYRAZINE