Basic information Safety Supplier Related

18-HYDROXY-11-DEOXYCORTICOSTERONE

Basic information Safety Supplier Related

18-HYDROXY-11-DEOXYCORTICOSTERONE Basic information

Product Name:
18-HYDROXY-11-DEOXYCORTICOSTERONE
Synonyms:
  • 11-DEOXY-18-HYDROXYCORTICOSTERONE
  • 18-HYDROXY-11-DEOXYCORTICOSTERONE
  • 18-HYDROXYDEOXYCORTICOSTERONE
  • 18-HYDROXY DOC
  • 18,20-EPOXY-20,21-DIHYDROXY-4-PREGNEN-3-ONE
  • 18,21-DIHYDROXY-4-PREGNENE-3,20-DIONE
  • 4-PREGNENE-18,21-DIOL-3,20-DIONE
  • 4-PREGNEN-18,21-DIOL-3,20-DIONE
CAS:
379-68-0
MF:
C21H30O4
MW:
346.46
EINECS:
2068343
Mol File:
379-68-0.mol
More
Less

18-HYDROXY-11-DEOXYCORTICOSTERONE Chemical Properties

Melting point:
171-173 °C
storage temp. 
2-8°C
solubility 
Chloroform (Slightly, Sonicated), Methanol (Slightly, Heated)
form 
Solid
color 
White to Off-White
LogP
1.571 (est)
More
Less

Safety Information

Safety Statements 
22-24/25
More
Less

18-HYDROXY-11-DEOXYCORTICOSTERONE Usage And Synthesis

Description

18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland. Its biosynthesis is regulated by adrenocorticotropic hormone (ACTH; ) as well as angiotensin II , which increases 18-OH-DOC production in isolated human adrenal glomerulosa cells. 18-OH-DOC can be formed via conversion of 11-deoxy corticosterone (DOC; ) in human SK-MEL188 melanoma cells. 18-OH-DOC is an intermediate in the metabolism of progesterone and can be converted to aldosterone by the capsular portion of rat adrenal glands. Continuous infusion of 18-OH-DOC (200 μg/rat per day) increases systolic blood pressure in uninephrectomized saline-drinking rats. Plasma levels of 18-OH-DOC are elevated in a db/db mouse model of type 2 diabetes.

Uses

11-Deoxy-18-hydroxycorticosterone is an analog of Corticosterone (C695700); a glucocorticoid and intermediate in the biosynthesis of Aldosterone (A514700) which is an adrenocortical steroid isolated from the adrenal cortex.

Definition

ChEBI: 18-hydroxydeoxycorticosterone is a 21-hydroxy steroid, a 3-oxo-Delta(4) steroid, a 20-oxo steroid and a 18-hydroxy steroid.

Purification Methods

Recrystallise 18-hydroxy-11-deoxycorticosterone from Et2O/Me2CO to give crystals m 200-205o. When it is recrystallised from M2CO, it has m 191-195o. It has UV with max at 240nm. The 21-O-acetoxy-18-hydroxy derivative has m 158-159o (from Et2O/*C6H6), and the 21-O-acetoxy-18,20-epoxy derivative has m 149-154o (from Et2O). [Kahnt et al. Helv Chim Acta 38 1237 1955; Pappo J Am Chem Soc 81 1010 1959.]

18-HYDROXY-11-DEOXYCORTICOSTERONESupplier

BOC Sciences
Tel
Email
info@bocsci.com
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Email
sales@chemegen.com
Energy Chemical
Tel
021-58432009 400-005-6266
Email
marketing@energy-chemical.com
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
Tel
17691182729 18161915376
Email
1046@dideu.com
Shanghai Saikerui Biotechnology Co. , Ltd.
Tel
021-58000709 15900491054
Email
info@scrbio.com