1-Oxa-8-azaspiro[4.5]decane, hydrochloride Chemical Properties

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

Appearance

White to light yellow Solid

Safety Information

HS Code 

2922500090

1-Oxa-8-azaspiro[4.5]decane, hydrochloride Usage And Synthesis

Synthesis

A methanolic hydrogen chloride solution (3M, 20 mL) was slowly added dropwise over 10 minutes to a stirred solution of tert-butyl 1-oxa-8-azaspiro[4.5]decane-8-carboxylate (3.18 g, 13.2 mmol) in methanol (10 mL) at 0 °C. After dropwise addition, the reaction mixture was continued to be stirred at room temperature for 3 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to afford 1-oxa-8-azaspiro[4.5]decane hydrochloride (2.29 g, 98% yield) as a white solid. Mass spectrometric analysis (ES+) showed m/z 142 ([M+H]+).

References

[1] Patent: US2003/236250, 2003, A1. Location in patent: Page 29
[2] Patent: WO2004/78750, 2004, A1. Location in patent: Page 78

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